15513-16-3Relevant articles and documents
Ruthenium Complex-catalyzed Novel and Facile Synthesis of Imidazopyridines from 2-Aminopyridines and vicinal-Diols
Kondo, Teruyuki,Kotachi, Shinji,Ogino, Shin-ichi,Watanabe, Yoshihisa
, p. 1317 - 1320 (1993)
Ruthenium complex-catalyzed N-heterocyclization of 2-aminopyridines with vicinal-diols offers a novel synthetic method for various imidazopyridines.For example, the reaction of 2-amino-4-methylpyridine with 1,2-cyclohexanediol in the presence of a catalytic amount of RuCl2(PPh3)3 under reflux in diglyme for 24 h afforded 2-methyl-6,7,8,9-tetrahydropyridobenzimidazole in 74percent yield.
Nucleophilic Difluoroalkylation of Isocyanates with Difluoromethyl 2-Pyridyl Sulfone
Li, Shan,Peng, Peng,Wei, Jun,Hu, Yongzhou,Hu, Jinbo,Sheng, Rong
, p. 3429 - 3434 (2015)
The nucleophilic difluoroalkylation of isocyanates with difluoromethyl 2-pyridyl sulfone furnished 2,2-difluoro-2-pyridinylsulfonylacetamides with good to excellent yield. These products can be converted to 2,2-difluoroacetamide sulfinate, iododifluoroacetamide and 2-aminopyridine derivatives easily.
Copper-catalyzed direct amination of benzylic hydrocarbons and inactive aliphatic alkanes with arylamines
Jin, Shengzhou,Lin, Sen,Xie, Bo,Yan, Zhaohua,Yao, Hua,Zhong, Xiaoyang
supporting information, p. 3263 - 3268 (2020/05/14)
A new synthetic method toward direct C-N bond formation through saturated C-H amination of benzylic hydrocarbons and inactive aliphatic alkanes with primary aromatic amines under an inexpensive catalyst/oxidant (Cu/DTBP) system has been developed. Both aminopyridines and anilines could react smoothly with primary and secondary benzylic C-H substrates or cyclohexane to form the corresponding aromatic secondary amines in moderate to good yields. This protocol has the advantages of wide functional group tolerance and use of readily available raw materials.
