156265-95-1Relevant articles and documents
The Silicon-Hydrogen Exchange Reaction: A Catalytic σ-Bond Metathesis Approach to the Enantioselective Synthesis of Enol Silanes
Zhou, Hui,Bae, Han Yong,Leutzsch, Markus,Kennemur, Jennifer L.,Bécart, Diane,List, Benjamin
, p. 13695 - 13700 (2020/08/24)
The use of chiral enol silanes in fundamental transformations such as Mukaiyama aldol, Michael, and Mannich reactions as well as Saegusa-Ito dehydrogenations has enabled the chemical synthesis of enantiopure natural products and valuable pharmaceuticals. However, accessing these intermediates in high enantiopurity has generally required the use of either stoichiometric chiral precursors or stoichiometric chiral reagents. We now describe a catalytic approach in which strongly acidic and confined imidodiphosphorimidates (IDPi) catalyze highly enantioselective interconversions of ketones and enol silanes. These "silicon-hydrogen exchange reactions"enable access to enantiopure enol silanes via tautomerizing σ-bond metatheses, either in a deprotosilylative desymmetrization of ketones with allyl silanes as the silicon source or in a protodesilylative kinetic resolution of racemic enol silanes with a carboxylic acid as the silyl acceptor.
Method for synthesizing trans-4-alkylcyclohexyl benzene structure liquid crystal intermediates and monomers
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, (2018/03/01)
The invention discloses a method for synthesizing trans-4-alkylcyclohexyl benzene structure liquid crystal intermediates and monomers and belongs to the technical field of trans-cyclohexyl benzene liquid crystal. The method comprises the following steps:
Compound having 2-fluorophenyloxymethane structure
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, (2015/12/01)
There is provided a compound having a good miscibility with another liquid crystal compound and having a combination of a low viscosity (η), high storage stability, and high T?i even after being used to produce a liquid crystal composition. In