156463-09-1Relevant articles and documents
A concise route to L-azidoamino acids: L-azidoalanine, L-azidohomo-alanine and L-azidonorvaline
Roth, Stefanie,Thomas, Neil R.
scheme or table, p. 607 - 609 (2010/09/18)
A simple and highly efficient synthetic route to three homologous azidoamino acids, starting from inexpensive, commercially available, protected natural amino acids is reported. The products can be used to introduce bioorthogonal handles into proteins. Ge
Presentation and detection of azide functionality in bacterial cell surface proteins
Link, A. James,Vink, Mandy K. S.,Tirrell, David A.
, p. 10598 - 10602 (2007/10/03)
An improved protocol for copper-catalyzed triazole formation on the bacterial cell surface is described. Addition of highly pure CuBr to cells treated with azidohomoalanine (2) leads to ca. 10-fold more extensive cell surface labeling than previously observed. This highly active catalyst allows detection of the methionine analogues azidoalanine (1), azidonorvaline (3), and azidonorleucine (4) in cell surface proteins. Azidoalanine was previously believed to be silent with regard to the cellular protein synthesis machinery.