156467-85-5 Usage
General Description
Alpha-conotoxin ImI is a peptide found in the venom of marine cone snails. It is a neurotoxin that specifically targets and inhibits the nicotinic acetylcholine receptors in the nervous system, leading to paralysis and potentially death in its prey. In scientific research, alpha-conotoxin ImI is used as a tool to study the structure and function of nicotinic acetylcholine receptors, and it has shown potential as a therapeutic agent for conditions related to these receptors, such as chronic pain and neurodegenerative diseases. However, its use is limited due to its potent and potentially harmful effects on the nervous system.
Check Digit Verification of cas no
The CAS Registry Mumber 156467-85-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,6,4,6 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 156467-85:
(8*1)+(7*5)+(6*6)+(5*4)+(4*6)+(3*7)+(2*8)+(1*5)=165
165 % 10 = 5
So 156467-85-5 is a valid CAS Registry Number.
InChI:InChI=1/C52H82N20O15S4/c1-24(41(78)66-30(15-25-18-61-27-8-3-2-7-26(25)27)44(81)64-28(9-4-12-59-51(55)56)42(79)69-33(20-88)40(54)77)62-46(83)35(22-90)70-43(80)29(10-5-13-60-52(57)58)65-49(86)37-11-6-14-72(37)50(87)31(16-39(75)76)67-45(82)32(19-73)68-48(85)36(23-91)71-47(84)34(21-89)63-38(74)17-53/h2-3,7-8,18,24,28-37,61,73,88-91H,4-6,9-17,19-23,53H2,1H3,(H2,54,77)(H,62,83)(H,63,74)(H,64,81)(H,65,86)(H,66,78)(H,67,82)(H,68,85)(H,69,79)(H,70,80)(H,71,84)(H,75,76)(H4,55,56,59)(H4,57,58,60)/t24-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-/m0/s1
156467-85-5Relevant articles and documents
3-Nitro-2-pyridinesulfenates as Efficient Solution- and Solid-Phase Disulfide Bond Forming Agents
Taguchi, Akihiro,Kobayashi, Kiyotaka,Kotani, Akira,Muguruma, Kyohei,Kobayashi, Misaki,Fukumoto, Kentarou,Takayama, Kentaro,Hakamata, Hideki,Hayashi, Yoshio
, p. 8262 - 8267 (2017)
In this paper, a new disulfide-forming agent based on the finding that alkoxy 3-nitro-2-pyridinesulfenates (Npys-OR) can oxidize thiol groups is reported. Methyl 3-nitro-2-pyridinesulfenate (Npys-OMe), which is easily prepared from 3-nitro-2-pyridinesulfenyl chloride in a one-step reaction and has a reduction peak potential (Epc) of ?0.541 V versus Ag/AgCl, produces the cyclic nonapeptide oxytocin from its linear form in good yield (92 %) with minimal oligomer formation. Npys-OMe in the solid phase also demonstrated excellent results in oxytocin synthesis. Other disulfide-containing peptides, such as α-human atrial natriuretic peptide and α-conotoxin ImI, were also successfully synthesized. During these syntheses, no side reactions of methionine (Met) and tryptophan (Trp) residues or the S-acetamidomethyl (Acm) protecting group were detected. These results suggested that Npys-OMe or its solid-phase analog provides a new strategy for regioselective disulfide bond formation to assist the synthesis of complex disulfide-rich peptides.
EPIMERIZATION-FREE N TO C SOLID-PHASE PEPTIDE SYNTHESIS
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Paragraph 0023; 0057; 0089; 0153, (2020/03/09)
The present disclosure provides a method of solid-phase peptide synthesis from the N terminus to C terminus without detectable epimerization of the C-terminal amino acid.
