156715-37-6Relevant articles and documents
Method for preparing homochiral maleimide intermediates, via silylation techniques
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, (2008/06/13)
A method is provided for preparing homochiral maleimide intermediates of the structure STR1 wherein R7, R8 and R9 are as defined herein by reacting a homochiral amine of the structure STR2 with maleic anhydride and a silylating agent. The maleimide intermediate is used in the enantio-selective preparation of thromboxane A2 receptor antagonists.
Method for preparing a benzaldehyde intermediate
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, (2008/06/13)
A method is provided for preparing a chiral benzaldehyde of the structure STR1 by acylating an anhydride of the structure STR2 with a chiral oxazolidine of the structure STR3 where Q is MgHal or Li, and X, Y and Z are as described herein, to form a keto acid which is reduced and cyclized. The resulting benzaldehyde may be used in making the final anti-thrombotic - anti-vasospastic compounds. Novel intermediates are also provided.