156991-90-1Relevant articles and documents
1,8-Naphthyridines II. 2,4-disubstituted N,N-dialkyl-1,8-naphthyridine - 3-carboxamides with anti-inflammatory and/or antiaggressive activities
Di Braccio,Roma,Ghia,Mattioli
, p. 25 - 32 (2007/10/02)
The preparation of the novel N,N-dialkyl-2,4-dichloro-1,8-naphthyridine- 3-carboxamides 1c,e and N,N-dialkyl-2-(alkylamino or cycloalkylamino)-4- chloro-1,8-naphthyridine-3-carboxamides 2b,d-g,j-p is described. These compounds and the previously obtained analogs 1a,b,d,f and 2a,c,h,i have been tested for their anti-inflammatory and antiaggressive activities, as well as for their gross behavioral effects and acute toxicity. Nine of the twenty- two tested compounds exhibited a statistically significant anti-inflammatory activity in the carrageenin-induced edema assay in the rat (1e,f and 2h,o were the most active compounds). On the other hand, an interesting antiaggressive activity was displayed by ten compounds in the isolation- induced aggressiveness test in mice (compounds 2d,i,k showed the highest activity). Structure-activity relationships are briefly discussed.
