160033-52-3Relevant articles and documents
Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling
Chen, Huifen,Volgraf, Matthew,Do, Steven,Kolesnikov, Aleksandr,Shore, Daniel G.,Verma, Vishal A.,Villemure, Elisia,Wang, Lan,Chen, Yong,Hu, Baihua,Lu, Ai-Jun,Wu, Guosheng,Xu, Xiaofeng,Yuen, Po-Wai,Zhang, Yamin,Erickson, Shawn D.,Dahl, Martin,Brotherton-Pleiss, Christine,Tay, Suzanne,Ly, Justin Q.,Murray, Lesley J.,Chen, Jun,Amm, Desiree,Lange, Wienke,Hackos, David H.,Reese, Rebecca M.,Shields, Shannon D.,Lyssikatos, Joseph P.,Safina, Brian S.,Estrada, Anthony A.
, p. 3641 - 3659 (2018/05/01)
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed in sensory neurons where it functions as an irritant sensor for a plethora of electrophilic compounds and is implicated in pain, itch, and respiratory disease. To s
HEPATITIS C VIRUS INHIBITORS
-
, (2012/04/10)
This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds
SYNTHESIS OF TRANS-5-METHYLPROLINE AND ITS INFLUENCE ON CIS-TRANS ISOMERISM IN &β-CASOMORPHIN-5
Tourwe, D.,Betsbrugge, J. Van,Verheyden, P.,Hootele, C.
, p. 201 - 206 (2007/10/02)
Starting from L-proline, trans-5-methylproline has been prepared using electrochemical oxidation followed by methylcopper substitution.After incorporation of this amino acid into β-casomorphin-5 at the two and four position, an NMR study revealed only limited influence on the cis/trans ratio of the peptide bond.The opioid receptor affinities did not allow to confirm the requirement for a cis Tyr-Pro peptide bond for biological activity.
