16049-49-3Relevant articles and documents
Quinofuracins A-E, produced by the fungus staphylotrichum boninense PF1444, show p53-dependent growth suppression
Tatsuda, Daisuke,Momose, Isao,Someno, Tetsuya,Sawa, Ryuichi,Kubota, Yumiko,Iijima, Masatomi,Kunisada, Takao,Watanabe, Takumi,Shibasaki, Masakatsu,Nomoto, Akio
supporting information, p. 188 - 195 (2015/03/18)
Quinofuracins A-E, novel anthraquinone derivatives containing β-d-galactofuranose that were isolated from the fungus Staphylotrichum boninense PF1444, induced p53-dependent cell death in human tumor cells. The structures of quinofuracins A-E, including absolute configurations, were elucidated by extensive spectroscopic analysis and chemical transformation studies. Quinofuracins were classified into three groups according to the aglycone moieties. 5'-Oxoaverantin was present in quinofuracins A-C, whereas averantin and versicolorin B were identified in quinofuracins D and E, respectively. These quinofuracins induced p53-dependent growth suppression in human glioblastoma LNZTA3 cells.