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161045-79-0

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161045-79-0 Usage

General Description

4-Bromo-2-chloro-6-fluorophenol is a chemical compound with the molecular formula C6H3BrClFO. It is a substituted phenol with a bromo, chloro, and fluoro group attached to the benzene ring. 4-BROMO-2-CHLORO-6-FLUOROPHENOL is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of dyes, polymers, and other organic compounds. 4-Bromo-2-chloro-6-fluorophenol is a highly reactive and potentially hazardous chemical, and proper safety precautions should be taken when handling and using this compound.

Check Digit Verification of cas no

The CAS Registry Mumber 161045-79-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,0,4 and 5 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 161045-79:
(8*1)+(7*6)+(6*1)+(5*0)+(4*4)+(3*5)+(2*7)+(1*9)=110
110 % 10 = 0
So 161045-79-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H3BrClFO/c7-3-1-4(8)6(10)5(9)2-3/h1-2,10H

161045-79-0 Well-known Company Product Price

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  • Alfa Aesar

  • (B24163)  4-Bromo-2-chloro-6-fluorophenol, 97+%   

  • 161045-79-0

  • 1g

  • 499.0CNY

  • Detail
  • Alfa Aesar

  • (B24163)  4-Bromo-2-chloro-6-fluorophenol, 97+%   

  • 161045-79-0

  • 5g

  • 1927.0CNY

  • Detail

161045-79-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Bromo-2-Chloro-6-Fluorophenol

1.2 Other means of identification

Product number -
Other names 4-Bromo-2-chloro-6-fluorophenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:161045-79-0 SDS

161045-79-0Synthetic route

4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

5-bromo-1-chloro-3-fluoro-2-(methoxymethoxy)benzene

5-bromo-1-chloro-3-fluoro-2-(methoxymethoxy)benzene

Conditions
ConditionsYield
With potassium carbonate In acetone at 0 - 20℃;99%
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

4-bromoethylbutanoate
2969-81-5

4-bromoethylbutanoate

4-(4-bromo-2-chloro-6-fluorophenoxy)butanoic acid ethyl ester

4-(4-bromo-2-chloro-6-fluorophenoxy)butanoic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 5h;97%
2-chloro-7-(1-ethylpropyl)-4-methoxy-1-methyl-1H-benzimidazole
913299-00-0

2-chloro-7-(1-ethylpropyl)-4-methoxy-1-methyl-1H-benzimidazole

4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

2-(4-bromo-2-chloro-6-fluorophenoxy)-7-(1-ethylpropyl)-4-methoxy-1-methyl-1H-benzimidazole
1022250-06-1

2-(4-bromo-2-chloro-6-fluorophenoxy)-7-(1-ethylpropyl)-4-methoxy-1-methyl-1H-benzimidazole

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 96h;16%
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

4-bromo-2-chloro-6-fluorophenol
1401717-51-8

4-bromo-2-chloro-6-fluorophenol

Conditions
ConditionsYield
With water-d2 for 168h;
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

2-fluoro-4-bromocyclopentadienylidenemethanone hydrochloride

2-fluoro-4-bromocyclopentadienylidenemethanone hydrochloride

Conditions
ConditionsYield
Wolff Rearrangement; UV-irradiation;
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

Isobutyl bromide
78-77-3

Isobutyl bromide

5-bromo-1-chloro-3-fluoro-2-isobutoxybenzene

5-bromo-1-chloro-3-fluoro-2-isobutoxybenzene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 0.5h;
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 0.5h;
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

benzyl 4-isobutyl-4-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

benzyl 4-isobutyl-4-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

benzyl (1-(4-bromo-2-chloro-6-fluorophenoxy)-2,4-dimethylpentan-2-yl)carbamate

benzyl (1-(4-bromo-2-chloro-6-fluorophenoxy)-2,4-dimethylpentan-2-yl)carbamate

Conditions
ConditionsYield
With sodium carbonate In 1-methyl-pyrrolidin-2-one at 50℃;
With sodium carbonate In 1-methyl-pyrrolidin-2-one at 50℃;
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

bromoacetic acid methyl ester
96-32-2

bromoacetic acid methyl ester

methyl 2-(4-bromo-2-chloro-6-fluorophenoxy)acetate

methyl 2-(4-bromo-2-chloro-6-fluorophenoxy)acetate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;2.53 g
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

C22H32ClFO5Si

C22H32ClFO5Si

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
2.1: titanium(IV) isopropylate / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere
3.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
4.2: 1 h / -78 - 20 °C
5.1: lithium chloride; trimethylsilyl cyanide / 2 h / 50 °C / Inert atmosphere
5.2: 0.5 h / -78 °C
5.3: 2 h / -78 °C
View Scheme
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

1-[(4-bromo-2-chloro-6-fluorophenoxy)methyl]cyclopropan-1-ol

1-[(4-bromo-2-chloro-6-fluorophenoxy)methyl]cyclopropan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
2: titanium(IV) isopropylate / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere
View Scheme
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

{1-[(4-bromo-2-chloro-6-fluorophenoxy)methyl]cyclopropyloxy}triethylsilane

{1-[(4-bromo-2-chloro-6-fluorophenoxy)methyl]cyclopropyloxy}triethylsilane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
2: titanium(IV) isopropylate / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere
3: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C
View Scheme
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

3-chloro-5-fluoro-4-{[1-(triethylsilyloxy)cyclopropyl]methoxy}benzaldehyde

3-chloro-5-fluoro-4-{[1-(triethylsilyloxy)cyclopropyl]methoxy}benzaldehyde

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
2.1: titanium(IV) isopropylate / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere
3.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
4.2: 1 h / -78 - 20 °C
View Scheme
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

6-{3-chloro-5-fluoro-4-[(1-hydroxycyclopropyl)methoxy]phenyl}-5-methyl-4,5-dihydro-2H-pyridazin-3-one

6-{3-chloro-5-fluoro-4-[(1-hydroxycyclopropyl)methoxy]phenyl}-5-methyl-4,5-dihydro-2H-pyridazin-3-one

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
2.1: titanium(IV) isopropylate / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere
3.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
4.2: 1 h / -78 - 20 °C
5.1: lithium chloride; trimethylsilyl cyanide / 2 h / 50 °C / Inert atmosphere
5.2: 0.5 h / -78 °C
5.3: 2 h / -78 °C
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
7.1: hydrazine hydrate; acetic acid / ethanol / 8 h / Reflux
View Scheme
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

methyl 4-{3-chloro-5-fluoro-4-[(1-hydroxycyclopropyl)methoxy]phenyl}-3-methyl-4-oxobutanoate

methyl 4-{3-chloro-5-fluoro-4-[(1-hydroxycyclopropyl)methoxy]phenyl}-3-methyl-4-oxobutanoate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
2.1: titanium(IV) isopropylate / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere
3.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
4.2: 1 h / -78 - 20 °C
5.1: lithium chloride; trimethylsilyl cyanide / 2 h / 50 °C / Inert atmosphere
5.2: 0.5 h / -78 °C
5.3: 2 h / -78 °C
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
View Scheme
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

A

5-bromo-1-chloro-2-(methoxymethoxy)-3-((2-methylallyl)oxy)benzene

5-bromo-1-chloro-2-(methoxymethoxy)-3-((2-methylallyl)oxy)benzene

B

5-bromo-1-chloro-2-(methoxymethoxy)-3-((2-methylprop-1-en-1-yl)oxy)benzene

5-bromo-1-chloro-2-(methoxymethoxy)-3-((2-methylprop-1-en-1-yl)oxy)benzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetone / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C
View Scheme
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

A

4-bromo-2-chloro-6-((2-methylallyl)oxy)phenol

4-bromo-2-chloro-6-((2-methylallyl)oxy)phenol

B

4-bromo-2-chloro-6-((2-methylprop-1-en-1-yl)oxy)phenol

4-bromo-2-chloro-6-((2-methylprop-1-en-1-yl)oxy)phenol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetone / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C
2.3: 20 °C
View Scheme
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

6-bromo-8-chloro-2,2-dimethyl-2,3-dihydrobenzo[b][1,4]dioxine

6-bromo-8-chloro-2,2-dimethyl-2,3-dihydrobenzo[b][1,4]dioxine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetone / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C
View Scheme
4-bromo-2-chloro-6-fluoro-phenol
161045-79-0

4-bromo-2-chloro-6-fluoro-phenol

8-chloro-6-iodo-2,2-dimethyl-2,3-dihydrobenzo[b][1,4]dioxine

8-chloro-6-iodo-2,2-dimethyl-2,3-dihydrobenzo[b][1,4]dioxine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetone / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C
3.1: trans-1,2-cyclohexanediamine; sodium iodide; copper(l) iodide / 1,4-dioxane / 115 °C / Inert atmosphere
View Scheme

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