161564-09-6Relevant articles and documents
Substituted pyridine compound and its method and use thereof
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, (2018/06/21)
The invention relates to a novel substitutive pyridine compound, and a pharmaceutically acceptable salt and a pharmaceutical preparation of the substitutive pyridine compound for regulating the activity of protein kinases and regulating signal responses between cells or in the cells. Meanwhile, the invention further relates to a pharmaceutical composition containing the compound provided by the invention, and a method for treating high proliferative diseases of mammals, especially human with the pharmaceutical composition.
Enantioselective diethylzinc addition to aromatic and aliphatic aldehydes using (3R,5R)-dihydroxypiperidine derivatives catalyst
Roudeau, Rémi,Gomez Pardo, Domingo,Cossy, Janine
, p. 2388 - 2394 (2007/10/03)
A series of chiral (3R,5R)-dihydroxypiperidine derivatives 3a-f were conveniently prepared from trans-4-hydroxy-l-proline and applied to the catalytic enantioselective addition of diethylzinc to benzaldehyde and heptanal. Among them, 3d was found to show
Design and synthesis of conformationally frozen peptide nucleic acid backbone: Chiral piperidine PNA as a hexitol nucleic acid surrogate
Lonkar, Pallavi S.,Kumar, Vaijayanti A.
, p. 2147 - 2149 (2007/10/03)
The design and facile synthesis of novel chiral piperidine PNA from naturally occurring 4-hydroxy-L-proline is reported. The stereospecific ring-expansion reaction to get six-membered piperidine derivative from 5-membered pyrrolidine derivative is exploit
