16173-52-7Relevant articles and documents
Mesogens based on cholesterol derivatives: Synthesis and characterization
Pandey, Ashwini,Singh, Bachcha
, p. 166 - 176 (2012)
A new series of liquid crystals involving cholesterol based mesogenic units and Schiff base moiety interlinked through ester linkage were designed and synthesized. The target compounds were obtained by the reaction of 4-(3-cholesteryl oxy carbonyl)benzald
Synthetic and structural study on some new porphyrin or metalloporphyrin macrocycle-containing model complexes for the active site of [FeFe]-hydrogenases
Song, Li-Cheng,Wang, Liang-Xing,Li, Chang-Gong,Li, Fengyu,Chen, Zhongfang
, p. 120 - 128 (2014)
To mimick the natural enzymes [FeFe]-hydrogenases, some new porphyrin and metalloporphyrin moiety-containing model complexes, namely 5-[p-Fe 2(CO)6(μ-SCH2)2CHO 2CC6H4],10,15,20-t
Scale-up of the synthesis of a pyrimidine derivative directly on solid support
Meisenbach, Mark,Allmendinger, Thomas,Mak, Ching-Pong
, p. 553 - 558 (2003)
The solid-phase synthesis of 4-(2-amino-6-phenylpyrimidin-4-yl)benzamide, a compound obtained through combinatorial chemistry and parallel synthesis, can be scaled up directly on solid support in excellent yields and high purity. By applying highly loaded aminomethyl polystyrene as solid support, a good ratio between the product and the starting resin is achieved. For comparison, the synthesis was also performed in solution. The solid-phase synthesis approach has the advantage that the desired compound is easily and quickly accessible in sufficient quantities for early development demands.
Distinct formation of a chiral smectic phase in achiral banana-shaped molecules with a central core based on a 2,7-dihydroxynaphthalene unit
Thisayukta, Jirakorn,Nakayama, Yusuke,Kawauchi, Susumu,Takezoe, Hideo,Watanabe, Junji
, p. 7441 - 7448 (2000)
We have prepared a novel series of banana-shaped molecules with a central bent core based on a 2,7-dihydroxynaphthalene group, the side wings containing a Schiff's based moiety, and alkoxy flexible tails with carbon numbers n = 6, 8, 10, 12, 14, and 16. Among these, the molecules with n = 8-16 formed a novel smectic phase. Its smectic layer possessed a liquidlike association of the molecules similar to the SmA or SmC phase, although the texture that developed from the isotropic melt was unconventional. Small fractal domains initially grew and then coalesced into several large domains. Very weak birefringence and fine structure without any anisotropy are characteristic of this phase. It is interesting to note that two different domains exist showing the opposite sign of optical rotation. Strong circular dichroism (CD) with a peak at 430 nm was also observed for each domain with the opposite sign. The results suggest a natural occurrence of the helix in these materials. The right-handed and left-handed helices were formed with equal probabilities, but the left-handed helix was selectively formed by the introduction of a chiral dopant. The molecule with n = 6 formed a frustrated smectic phase, which exhibited a simple fan-shaped texture.
Prato reaction derived polythiophene/C60donor-acceptor double cable polymer, fabrication of photodetectors and evaluation of photocurrent generation
Iftikhar, Sunniya,Aslam, Saba,Butt, Nauman Zafar,Ashraf, Raja Shahid,Yameen, Basit
, p. 17365 - 17373 (2020)
Herein, a side chain engineered polythiophene copolymer based organic semiconductor polymer (OSP) with pendant aldehyde groups was synthesized by a combination of Grignard Metathesis (GRIM) polymerization and post-synthetic modifications. The pendant alde
Catalytic hydroamination of unactivated olefins using a Co catalyst for complex molecule synthesis
Shigehisa, Hiroki,Koseki, Natsumi,Shimizu, Nao,Fujisawa, Mayu,Niitsu, Makoto,Hiroya, Kou
, p. 13534 - 13537 (2014)
Functional group tolerance is one of the important requirements for chemical reactions, especially for the synthesis of complex molecules. Herein, we report a mild, general, and functional group tolerant intramolecular hydroamination of unactivated olefins using a Co(salen) complex, an N-fluoropyridinium salt, and a disiloxane reagent. This method, which was carried out at room temperature (or 0 °C), afforded three-, five-, six-, and seven-membered ring nitrogen-containing heterocyclic compounds and was compatible with diverse functional groups.
C2 symmetric borneol-porphyrin hybrids: Synthesis, characterization, electronic structure and their anti-cancer behaviors
Dong, Xinyi,Fang, Xianying,Fu, Bo,Liang, Xu,Xu, Haijun,Yu, Xiaoxiao,Zhang, Zhen,Zhu, Weihua
, (2020/09/17)
A series of five C2 Symmetric A2B2 type borneol-porphyrin hybrids have been synthesized and characterized. Moreover, a detailed analysis of their optical and redox properties was carried out by comparing the results obtained via optical spectroscopy and electrochemistry. The current results demonstrated that the meso borneol-substitutions excitation coupled strongly with porphyrin core that leads to significant CD signals in the Soret band region, and molecular anti-cancer behaviors were also investigated.
Discovery of N-(3,4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2- c]quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor
Wu, Zhongzhi,Gu, Lubing,Zhang, Sicheng,Liu, Tao,Lukka, Pradeep B.,Meibohm, Bernd,Bollinger, John C.,Zhou, Muxiang,Li, Wei
, p. 1930 - 1950 (2021/03/01)
Murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP) are important cell survival proteins in tumor cells. As a dual MDM2/XIAP inhibitor reported previously, compound MX69 has low potency with an IC50 value of 7.5 μM against an acute lymphoblastic leukemia cell line EU-1. Herein, we report the structural optimization based on the MX69 scaffold, leading to the discovery of a 25-fold more potent analogue 14 (IC50 = 0.3 μM against EU-1). We demonstrate that 14 maintains its mode of action by dual targeting of MDM2 and XIAP through inducing MDM2 protein degradation and inhibiting XIAP mRNA translation, respectively, which resulted in cancer cell growth inhibition and cell death. The results strongly suggest that the scaffold based on 14 is promising for further optimization to develop a new therapeutic agent for leukemia and possibly other cancers where MDM2 and XIAP are dysregulated.
