163131-87-1Relevant articles and documents
Asymmetric total synthesis of caribenol A via an intramolecular diels-alder reaction
Han, Jing-Chun,Liu, Lian-Zhu,Chang, Yuan-Yuan,Yue, Guo-Zong,Guo, Jie,Zhou, Li-Yan,Li, Chuang-Chuang,Yang, Zhen
, p. 5492 - 5504 (2013/07/26)
A total synthesis of the caribenol A (1), a novel natural product with an intriguing tetracyclic framework, has been achieved. The synthesis features an intramolecular Diels-Alder (IMDA) reaction for the facile construction of the tricyclic [5-7-6] skelet
Stereoselective synthesis of 4'-α-alkylcarbovir derivatives based on an asymmetric synthesis or chemoenzymatic procedure
Kato, Keisuke,Suzuki, Hisaki,Tanaka, Hiromichi,Miyasaka, Tadashi,Baba, Masanori,Yamaguchi, Kentaro,Akita, Hiroyuki
, p. 1256 - 1264 (2007/10/03)
Stereoselective synthesis of 4'-α-alkylcarbovir derivatives 4 was described based on asymmetric synthesis or a chemoenzymatic procedure. The asymmetric alkylation of chiral acetal 7 gave the alkylated enol ethers 9a - c possessing a chiral quaternary carbon. The key carbocyclic intermediates 14a - c were synthesized from 9a - c via eleven-steps. Coupling of 14a - c with 2-amino-6-chloropurine followed by desilylation and subsequent hydrolysis afforded the target compounds 4a - c in moderate yield. The optically active cyclopentene intermediates 5a - c and 6a - c were also prepared by enzymatic resolution of (±)-5a - c and (±)-6a - c, respectively.
