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16365-27-8

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16365-27-8 Usage

Chemical Properties

Light yellow solid

Uses

2-(p-Nitrophenoxy)ethanol is used in preparation of inimer containing azobenzene group for polymerization of N-isopropylacrylamid.

Check Digit Verification of cas no

The CAS Registry Mumber 16365-27-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,3,6 and 5 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 16365-27:
(7*1)+(6*6)+(5*3)+(4*6)+(3*5)+(2*2)+(1*7)=108
108 % 10 = 8
So 16365-27-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO4/c10-5-6-13-8-3-1-7(2-4-8)9(11)12/h1-4,10H,5-6H2

16365-27-8Relevant articles and documents

Molecular rulers: New families of molecules for measuring interfacial widths

Steel, William H.,Damkaci, Fehmi,Nolan, Ryan,Walker, Robert A.

, p. 4824 - 4831 (2002)

Homologous series of solvatochromic neutral alcohols and ionic sulfates are synthesized and characterized. Each surfactant series consists of hydrophobic, p-nitroanisole-based chromophores attached to polar or ionic headgroups by n-alkyl spacers. UV absorption measurements show that the optical properties of surfactant chromophores closely track those of the parent chromophore. Interfacial tension measurements are used to calculate surface excess concentrations of ionic surfactants adsorbed to an aqueous-cyclohexane interface. With a hydrophobic chromophore, a hydrophilic headgroup, and a variable-length, alkyl spacer, these surfactants have the potential to function as molecular rulers: probes of molecular-scale variation in solvation forces across condensed-phase interfaces. Changing the separation between the hydrophobic, solvatochromic probe and the hydrophilic headgroup should enable different members of a homologous series to span different interfacial widths, thus exposing the chromophore to different chemical environments. This idea is explored by using surface-specific, nonlinear optical spectroscopy. Resonant second harmonic spectra of p-nitroanisole and the surfactant product 4a adsorbed to an aqueous-cyclohexane interface show the surfactant spectrum blue-shifted 9 nm relative to the spectrum of adsorbed p-nitroanisole. On the basis of chromophore solvatochromism, these results are consistent with a less polar environment surrounding the surfactant chromophore. Significant differences in interfacial solvation resulting from a ~5 A separation between the surfactant headgroup and chromophore support recently proposed models of molecularly sharp, microscopically flat aqueous-alkane interfaces.

Solvent polarity across weakly associating interfaces

Steel, William H.,Lau, Yuen Y.,Beildeck, Carmen L.,Walker, Robert A.

, p. 13370 - 13378 (2004)

Molecular ruler surfactants, solvatochromic probes of solvent polarity, have been used to examine changes in solvent polarity across weakly associating liquid/liquid interfaces. The water/alkane interfaces were formed between an aqueous subphase and either cyclic (cyclohexane and methylcyclohexane) or linear (octane and hexadecane) alkanes. Resonance-enhanced second-harmonic generation was used to collect effective excitation spectra of species adsorbed to these interfaces. As surfactants lengthened, the surfactant probe sampled an increasingly nonpolar environment as evidenced by an excitation wavelength that shifted toward the alkane limit. Data suggest that all four water/alkane interfaces are molecularly sharp (9 Aì?), but that differences in the solvent molecular structure alter the transition from aqueous to organic solvation across the interface. Polarity across two interfaces (cyclohexane and hexadecane) changes gradually over the distance spanned by ruler surfactants. In contrast, the transitions at the interfaces between water and methylcyclohexane and octane appear much more abrupt. These findings appear to correlate with each organic solvent's ability to pack and associated free volume. More free volume in the organic phase leads to a more abrupt water/alkane interface. Results are interpreted on the basis of recent molecular dynamics simulations examining polarity at different water/monolayer interfaces.

Synthetic and Mechanistic Studies on 2,3-Dihydrobenzo[ b ][1,4]-oxaselenines Formation from Selenocyanates

Bonesi, Sergio M.,Cattaneo, Mauricio,Chao, María N.,Rodriguez, Juan B.,Sanchez Gonzalez, Jonathan,Szajnman, Sergio H.

, p. 1643 - 1658 (2020/05/25)

An expedient preparation of selenium-containing hetero-cycles via an m -chloroperbenzoic acid-mediated seleno-annulation starting from selenocyanate derivatives is described. In spite of its significance, this cyclization reaction is virtually understudied not only from the point of view of its scope, but also from the mechanistic aspects associated to this remarkable transformation. In this sense, several selenocyanate and thiocyanate derivatives bearing an aromatic ring were evaluated as substrates under different reaction conditions of this interesting cyclization yielding important insights on its scope as well as relevant information on the reaction mechanism.

Design, synthesis, and biological evaluation of some novel 4-aminoquinazolines as Pan-PI3K inhibitors

Ding, Huai-Wei,Wang, Shu,Qin, Xiao-Chun,Wang, Jian,Song, Hong-Rui,Zhao, Qing-Chun,Song, Shao-Jiang

, p. 2729 - 2740 (2019/05/17)

A series of 4-aminoquinazolines derivatives containing hydrophilic group were designed and identified as potent Pan-PI3K inhibitors in this study. The results of antiproliferative assays in vitro showed that this series of compounds had strong inhibition of tumor growth, especially compound 7b for MCF-7 cells but weak inhibition to normal cells. PI3K kinase assay showed that 7b had high activity for three PI3K isoforms with the IC50 values of picomole. The western blot assay indicated that 7b could decrease the phospho-Akt (S473) in a dose-dependent manner. Further experiments showed that 7b could induce apoptosis in MCF-7 cells. Four key hydrogen bonding interactions were found in the docking of 7b with PI3K kinase. All these results suggested that 7b is a potent PI3K inhibitor and could be considered as a potential candidate for the development of anticancer agents.

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