163860-25-1 Usage
Description
5-fluoro-3-(3-(piperazin-1-yl)propyl)-1H-indole, commonly referred to as 5F-MDMB-PICA, is a synthetic cannabinoid that functions as a potent agonist of the CB1 receptor. This psychoactive substance is known for its recreational use and is often marketed under the guise of "herbal incense" or "potpourri." Structurally, it shares similarities with THC, the primary psychoactive component in marijuana, and is reported to elicit comparable effects such as relaxation, euphoria, and altered perception. However, the high potency and unpredictable nature of 5F-MDMB-PICA have led to numerous adverse reactions, prompting its ban in several jurisdictions.
Uses
Used in Recreational Drug Industry:
5-fluoro-3-(3-(piperazin-1-yl)propyl)-1H-indole is used as a psychoactive substance for recreational purposes due to its ability to mimic the effects of THC, providing users with a sense of relaxation, euphoria, and altered perception. However, its high potency and potential for adverse reactions have raised significant health and safety concerns, leading to its prohibition in various countries.
Check Digit Verification of cas no
The CAS Registry Mumber 163860-25-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,3,8,6 and 0 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 163860-25:
(8*1)+(7*6)+(6*3)+(5*8)+(4*6)+(3*0)+(2*2)+(1*5)=141
141 % 10 = 1
So 163860-25-1 is a valid CAS Registry Number.
163860-25-1Relevant articles and documents
A class of indole derivatives and preparation methods and uses thereof
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Paragraph 0032; 0043-0044; 0072; 0082-0083, (2022/01/12)
The present invention relates to the field of medicinal chemistry, discloses a class of indole derivatives and preparation methods and uses thereof. The present invention also discloses a compound comprising the indole structure or a pharmaceutically acce
Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor
Pessoa-Mahana, Hernán,González-Lira, Christian,Fierro, Angélica,Zapata-Torres, Gerald,Pessoa-Mahana, C. David,Ortiz-Severin, Javiera,Iturriaga-Vásquez, Patricio,Reyes-Parada, Miguel,Silva-Matus, Paul,Saitz-Barría, Claudio,Araya-Maturana, Ramiro
, p. 7604 - 7611 (2014/01/06)
A series of 3-(3-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)propyl)-1H- indole derivatives (3a-d and 5a-f) as homo- and hetero-bis-ligands, were synthesized and evaluated for in vitro affinity at the serotonin transporter (SERT) and the 5-HT1A receptor. Compounds 5b and 5f showed nanomolar affinities for both targets. The experimental data were rationalized according to results obtained from docking experiments. These findings are in agreement with our proposal that bis-indole derivatives can bind both targets, and might serve as leads in the quest of ligands endowed with a dual mechanism of action.
