16499-64-2Relevant articles and documents
Stereoselective Bulk Synthesis of CCR2 Antagonist BMS-741672: Assembly of an All-cis (S,R,R)-1,2,4-Triaminocyclohexane (TACH) Core via Sequential Heterogeneous Asymmetric Hydrogenations
Deerberg, Joerg,Prasad, Siva J.,Sfouggatakis, Chris,Eastgate, Martin D.,Fan, Yu,Chidambaram, Ramakrishnan,Sharma, Praveen,Li, Li,Schild, Richard,Müslehiddino?lu, Jale,Chung, Hyei-Jha,Leung, Simon,Rosso, Victor
, p. 1949 - 1966 (2017/02/10)
A concise bulk synthesis of stereochemically complex CCR2 antagonist BMS-741672 is reported. A distinct structural feature is the chiral all-cis 1,2,4-triaminocyclohexane (TACH) core, which was assembled through consecutive stereocontrolled heterogeneous
Cyclic derivatives as modulators of chemokine receptor activity
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Page/Page column 41, (2008/06/13)
The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.
N-ALKYLATED DIAMINOPROPANE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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Page/Page column 143, (2010/02/11)
The present application describes modulators of MCP-1 of formula (I), or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.