16535-98-1Relevant articles and documents
INHIBITORS OF LYSINE METHYL TRANSFERASE
-
Page/Page column 47, (2015/06/08)
There are disclosed compounds that are inhibitors of EZH2, pharmaceutical compositions containing said compounds and methods of treating hyperproliferative, inflammatory, infectious, and immunoregulatory disorders and diseases, utilizing the compounds of
Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding
Beausoleil, Eric,Chauvignac, Cedric,Taverne, Thierry,Lacombe, Sandrine,Pognante, Laure,Leblond, Bertrand,Pallares, Diego,Oliveira, Catherine De,Bachelot, Florence,Carton, Rachel,Peillon, Helene,Coutadeur, Severine,Picard, Virginie,Lambeng, Nathalie,Desire, Laurent,Schweighoffer, Fabien
scheme or table, p. 5594 - 5598 (2010/04/05)
The synthesis of a series of berberine, phenantridine and isoquinoline derivatives was realized to explore their Rho GTPase nucleotide inhibitory activity. The compounds were evaluated in a nucleotide binding competition assay against Rac1, Rac1b, Cdc42 and in a cellular Rac GTPase activation assay. The insertion of 19 AA in the splice variant Rac1b is shown to be sufficient to introduce a conformational difference that allows compounds 4, 21, 22, and 26 to exhibit selective inhibition of Rac 1b over Rac1.
Synthesis of isoquinolines from 2-phenylethylamines, amides, nitriles and carboxylic acids in polyphosphoric acid
Venkov, Atanas P.,Ivanov, Ilian I.
, p. 12299 - 12308 (2007/10/03)
A convenient one pot synthesis of 1-, 1.3-substituted 3,4-dihydroisoquinolines 5 enamines 10 and 3-oxo-2,3-dihydroisoquinolines 18 as well as of enamides 22 of isoquinoline from 2-phenyl-, 1,2-diphenylethylamines, phenylacetamides, phenylacetonitriles, N-acylphenylethylamines and carboxylic acids in nonaqueous media has been accomplished.
