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16541-19-8

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  • Guanosine5'-(trihydrogen diphosphate), 6-thio-

    Cas No: 16541-19-8

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16541-19-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 16541-19-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,5,4 and 1 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 16541-19:
(7*1)+(6*6)+(5*5)+(4*4)+(3*1)+(2*1)+(1*9)=98
98 % 10 = 8
So 16541-19-8 is a valid CAS Registry Number.

16541-19-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name O5'-trihydroxydiphosphoryl-6-thio-guanosine

1.2 Other means of identification

Product number -
Other names Thioguanosine Diphosphate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16541-19-8 SDS

16541-19-8Upstream product

16541-19-8Downstream Products

16541-19-8Relevant articles and documents

Enzymatic Thioamide Formation in a Bacterial Antimetabolite Pathway

Litomska, Agnieszka,Ishida, Keishi,Dunbar, Kyle L.,Boettger, Marco,Coyne, Sébastien,Hertweck, Christian

, p. 11574 - 11578 (2018/09/10)

6-Thioguanine (6TG) is a DNA-targeting therapeutic used in the treatment of various cancers. While 6TG was rationally designed as a proof of concept for antimetabolite therapy, it is also a rare thioamide-bearing bacterial natural product and critical virulence factor of Erwinia amylovorans, plant pathogens that cause fire blight. Through gene expression, biochemical assays, and mutational analyses, we identified a specialized bipartite enzyme system, consisting of an ATP-dependent sulfur transferase (YcfA) and a sulfur-mobilizing enzyme (YcfC), that is responsible for the peculiar oxygen-by-sulfur substitution found in the biosynthesis of 6TG. Mechanistic and phylogenetic studies revealed that YcfA-mediated 6TG biosynthesis evolved from ancient tRNA modifications that support translational fidelity. The successful in vitro reconstitution of 6TG thioamidation showed that YcfA employs a specialized sulfur shuttle that markedly differs from universal RNA-related systems. This study sheds light on underexplored enzymatic C?S bond formation in natural product biosynthesis.

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