16576-78-6Relevant articles and documents
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Schunack
, p. 934,941 (1973)
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THERAPEUTIC COMPOUNDS AND USES THEREOF
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Paragraph 0377; 0378, (2015/03/16)
The present invention relates to compounds formula (I): and to salts thereof, wherein R1-R4 and A have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of histone demethylases, such as KDM5. Also included are pharmaceutically acceptable compositions comprising the compounds of the present invention and methods of using said compositions in the treatment of various disorders.
Conjugated indole-imidazole derivatives displaying cytotoxicity against multidrug resistant cancer cell lines
James, David A.,Koya, Keizo,Li, Hao,Chen, Shoujun,Xia, Zhiqiang,Ying, Weiwen,Wu, Yaming,Sun, Lijun
, p. 5164 - 5168 (2007/10/03)
We report herein the SAR studies of a series of indole-imidazole compounds. that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes. The in vitro cytotoxic effects have