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16588-75-3

16588-75-3

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16588-75-3 Usage

General Description

2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE is a chemical compound with the molecular formula C9H6F3NO2. It is a colorless liquid with a sharp, pungent odor and is used in the production of polymers, coatings, adhesives, and foams. It is a highly reactive compound and can cause irritation to the skin, eyes, and respiratory system upon contact or inhalation. It is important to handle and store this chemical with caution and in accordance with safety regulations to minimize the risk of exposure and potential harm to human health and the environment.

Check Digit Verification of cas no

The CAS Registry Mumber 16588-75-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,5,8 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 16588-75:
(7*1)+(6*6)+(5*5)+(4*8)+(3*8)+(2*7)+(1*5)=143
143 % 10 = 3
So 16588-75-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H6F3NO2/c1-15-8-3-2-6(9(10,11)12)4-7(8)13-5-14/h2-4H,1H3

16588-75-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Methoxy-5-Trifluoromethylphenyl Isocyanate

1.2 Other means of identification

Product number -
Other names 2-isocyanato-1-methoxy-4-(trifluoromethyl)benzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16588-75-3 SDS

16588-75-3Synthetic route

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

Conditions
ConditionsYield
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In dichloromethane at 0 - 20℃; for 1.5h;88%
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In dichloromethane at 0 - 20℃; for 1.5h;88%
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In dichloromethane at 0 - 20℃; for 1.5h;88%
phosgene
75-44-5

phosgene

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

Conditions
ConditionsYield
With pyridine In diethyl ether; dichloromethane; toluene
With pyridine In dichloromethane; toluene at 0 - 20℃; for 3.5h;
With sodium hydrogencarbonate In dichloromethane; water at 0℃; for 0.5h;
4-(4-acetylphenoxy)-5-aminopyridine
284670-99-1

4-(4-acetylphenoxy)-5-aminopyridine

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

N,N,N',N'-tetramethyl-1,8-diaminonaphthalene
20734-58-1

N,N,N',N'-tetramethyl-1,8-diaminonaphthalene

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

Conditions
ConditionsYield
In dichloromethane
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

Conditions
ConditionsYield
With pyrographite In ethyl acetate for 2h; Reflux;
5-(4-aminophenoxy)isoindoline-1,3-dione
284462-39-1

5-(4-aminophenoxy)isoindoline-1,3-dione

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

N-(2-methoxy-5-(trifluoromethyl)phenyl)-N'-(4-(1,3-dioxoisoindolin-5-yloxy)phenyl)urea

N-(2-methoxy-5-(trifluoromethyl)phenyl)-N'-(4-(1,3-dioxoisoindolin-5-yloxy)phenyl)urea

Conditions
ConditionsYield
In dichloromethane at 0 - 20℃; for 12 - 22h; Product distribution / selectivity;96%
2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

2-bromo-6-fluoroaniline
65896-11-9

2-bromo-6-fluoroaniline

3-(2-bromo-6-fluorophenyl)-1-[2-methoxy-5-(trifluoromethyl)phenyl]urea
917389-23-2

3-(2-bromo-6-fluorophenyl)-1-[2-methoxy-5-(trifluoromethyl)phenyl]urea

Conditions
ConditionsYield
In acetonitrile at 35 - 88℃; for 38 - 45h; Product distribution / selectivity;87.5%
2-Fluoroaniline
348-54-9

2-Fluoroaniline

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea
917389-24-3

N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea

Conditions
ConditionsYield
In acetonitrile at 82℃; for 4h;86.4%
In acetonitrile for 4h; Reflux; Large scale;85.9%
In acetonitrile at 0℃; for 7.25h; Reflux; Large scale;85.9%
In acetonitrile for 4h; Reflux; Large scale;85.9%
In acetonitrile Reflux;
N-(4-fluoro-3-methylphenyl)-piperazine
140479-05-6

N-(4-fluoro-3-methylphenyl)-piperazine

(2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester
791117-28-7

(2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

{8-fluoro-2-[4-(4-fluoro-3-methylphenyl)-1-piperazinyl]-3-[6-methoxy-3-(trifluoro-methyl)phenyl]-3,4-dihydro-4-quinazolinyl}-acetic acid methyl ester

{8-fluoro-2-[4-(4-fluoro-3-methylphenyl)-1-piperazinyl]-3-[6-methoxy-3-(trifluoro-methyl)phenyl]-3,4-dihydro-4-quinazolinyl}-acetic acid methyl ester

Conditions
ConditionsYield
79%
(2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester
791117-28-7

(2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

methyl (2E)-3-(3-fluoro-2-((((2-methoxy-5-(trifluoromethyl)phenyl)imino)methylene)amino)phenyl)acrylate

methyl (2E)-3-(3-fluoro-2-((((2-methoxy-5-(trifluoromethyl)phenyl)imino)methylene)amino)phenyl)acrylate

Conditions
ConditionsYield
In dichloromethane at 20℃;62%
2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

3-chloro-aniline
108-42-9

3-chloro-aniline

1-(3-chlorophenyl)-3-(2-methoxy-5-(trifluoromethyl)phenyl)urea

1-(3-chlorophenyl)-3-(2-methoxy-5-(trifluoromethyl)phenyl)urea

Conditions
ConditionsYield
In dichloromethane at 0℃; for 0.75h;55%
9-methyl-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole
796069-32-4

9-methyl-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole

(2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester
791117-28-7

(2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

[8-fluoro-3-(2-methoxy-5-trifluoromethyl-phenyl)-2-(9-methyl-3,4-dihydro-1H-pyrazino[1,2-a]indol-2-yl)-3,4-dihydro-quinazolin-4-yl]acetic acid methyl ester
796069-35-7

[8-fluoro-3-(2-methoxy-5-trifluoromethyl-phenyl)-2-(9-methyl-3,4-dihydro-1H-pyrazino[1,2-a]indol-2-yl)-3,4-dihydro-quinazolin-4-yl]acetic acid methyl ester

Conditions
ConditionsYield
Stage #1: (2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester; 2-methoxy-5-trifluoromethylphenyl isocyanate In dichloromethane at 20℃;
Stage #2: 9-methyl-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole With silica gel In 1,4-dioxane; dichloromethane at 20℃; Heating / reflux;		42%
2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

(2E)-3-{2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester
138386-58-0

(2E)-3-{2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester

(2E)-3-{2-[(iminomethylen)amino]phenyl}-acrylic acid methyl ester-1-methoxy-4-(trifluoromethyl)-benzene

(2E)-3-{2-[(iminomethylen)amino]phenyl}-acrylic acid methyl ester-1-methoxy-4-(trifluoromethyl)-benzene

Conditions
ConditionsYield
In dichloromethane at 20℃;38%
2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

4-fluoroaniline
371-40-4

4-fluoroaniline

N-(2-methoxy-5-(trifluoromethyl)phenyl)-N'-(4-fluorophenyl)urea

N-(2-methoxy-5-(trifluoromethyl)phenyl)-N'-(4-fluorophenyl)urea

Conditions
ConditionsYield
In ethyl acetate
In ethyl acetate at 20℃; for 72h;
In ethyl acetate at 20℃; for 72h;
In ethyl acetate at 20℃; for 72h; Product distribution / selectivity;
C19H23N5O

C19H23N5O

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

1-{4-[2-(2-dimethylamino-ethylamino)-6-methyl-pyrimidin-4-yloxy]-naphthalen-1-yl}-3-(2-methoxy-5-trifluoromethyl-phenyl)-urea

1-{4-[2-(2-dimethylamino-ethylamino)-6-methyl-pyrimidin-4-yloxy]-naphthalen-1-yl}-3-(2-methoxy-5-trifluoromethyl-phenyl)-urea

Conditions
ConditionsYield
In tetrahydrofuran at 20℃;
C20H22N4O2

C20H22N4O2

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

1-(2-methoxy-5-trifluoromethyl-phenyl)-3-[4-(6-methyl-2-morpholin-4-ylmethyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea

1-(2-methoxy-5-trifluoromethyl-phenyl)-3-[4-(6-methyl-2-morpholin-4-ylmethyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃;
3-(2-pyridin-4-yl-imidazol-1-ylmethyl)-phenylamine

3-(2-pyridin-4-yl-imidazol-1-ylmethyl)-phenylamine

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

1-(2-methoxy-5-trifluoromethyl-phenyl)-3-[3-(2-pyridin-4-yl-imidazol-1-ylmethyl)-phenyl]-urea

1-(2-methoxy-5-trifluoromethyl-phenyl)-3-[3-(2-pyridin-4-yl-imidazol-1-ylmethyl)-phenyl]-urea

Conditions
ConditionsYield
In dichloromethane; N,N-dimethyl-formamide
4-(4-acetylphenoxy)-5-aminopyridine
284670-99-1

4-(4-acetylphenoxy)-5-aminopyridine

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

4-Hydroxyacetophenone
99-93-4

4-Hydroxyacetophenone

1-(4-(4-nitrophenoxy)phenyl)ethanone
75919-92-5

1-(4-(4-nitrophenoxy)phenyl)ethanone

4-chloro-pyridine-2-carbonyl chloride
53750-66-6

4-chloro-pyridine-2-carbonyl chloride

3-(4-(2-(N-methylcarbamoyl)phenylthio)aniline

3-(4-(2-(N-methylcarbamoyl)phenylthio)aniline

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

isopropylamine
75-31-0

isopropylamine

A

4-(2-(N-isopropylcarbamoyl)-pyridin-4-yloxy)aniline
284462-89-1

4-(2-(N-isopropylcarbamoyl)-pyridin-4-yloxy)aniline

B

4-amino-phenol
123-30-8

4-amino-phenol

4-(4-(2-(N-methylcarbamoyl)phenylthio)aniline

4-(4-(2-(N-methylcarbamoyl)phenylthio)aniline

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

5-(4-aminophenoxy)-2-methylisoindoline-1,3-dione

5-(4-aminophenoxy)-2-methylisoindoline-1,3-dione

4-(4-amino-3-chloro-phenoxy)-pyridine-2-carboxylic acid methylamide
284462-44-8

4-(4-amino-3-chloro-phenoxy)-pyridine-2-carboxylic acid methylamide

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

amino-4 hydroxy-2 toluene
2835-95-2

amino-4 hydroxy-2 toluene

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

A

3-(2-(N-methylcarbamoyl)-pyridin-4-yloxy)-4-methylaniline
284462-92-6

3-(2-(N-methylcarbamoyl)-pyridin-4-yloxy)-4-methylaniline

B

4-chloro-N-methylpicolinamide
220000-87-3

4-chloro-N-methylpicolinamide

4-(4-aminophenoxy)-N,N-dimethylpicolinamide
284462-86-8

4-(4-aminophenoxy)-N,N-dimethylpicolinamide

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

4-(1-oxoisoindolin-5-yloxy)aniline
284462-54-0

4-(1-oxoisoindolin-5-yloxy)aniline

4-(2-(N-isopropylcarbamoyl)-pyridin-4-yloxy)aniline
284462-89-1

4-(2-(N-isopropylcarbamoyl)-pyridin-4-yloxy)aniline

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

methyl 5-(4-aminophenoxy)pyridine-3-carboxylate
284462-58-4

methyl 5-(4-aminophenoxy)pyridine-3-carboxylate

N-methylphthalimide
550-44-7

N-methylphthalimide

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

4-chloro-N-methylpicolinamide
220000-87-3

4-chloro-N-methylpicolinamide

5-methyl-1-(pyridin-4-yl)methyl-1H-benzimidazol-4-ylamine
915295-45-3

5-methyl-1-(pyridin-4-yl)methyl-1H-benzimidazol-4-ylamine

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

1-(2-Methoxy-5-trifluoromethyl-phenyl)-3-(5-methyl-1-pyridin-4-ylmethyl-1H-benzoimidazol-4-yl)-urea

1-(2-Methoxy-5-trifluoromethyl-phenyl)-3-(5-methyl-1-pyridin-4-ylmethyl-1H-benzoimidazol-4-yl)-urea

Conditions
ConditionsYield
In dichloromethane for 4h;
1-(Pyridin-4-yl)methyl-1H-benzimidazol-4-ylamine
915295-51-1

1-(Pyridin-4-yl)methyl-1H-benzimidazol-4-ylamine

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

1-(2-Methoxy-5-trifluoromethyl-phenyl)-3-(1-pyridin-4-ylmethyl-1H-benzoimidazol-4-yl)-urea

1-(2-Methoxy-5-trifluoromethyl-phenyl)-3-(1-pyridin-4-ylmethyl-1H-benzoimidazol-4-yl)-urea

Conditions
ConditionsYield
In dichloromethane; N,N-dimethyl-formamide at 20℃; for 16h;
6-(3-aminophenyl)-N-(pyridin-4-ylmethyl)imidazo[1,2-a]pyrazin-8-amine
1044656-17-8

6-(3-aminophenyl)-N-(pyridin-4-ylmethyl)imidazo[1,2-a]pyrazin-8-amine

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

1-(2-metoxy-5-trifluoromethyl-phenyl)-3-(3-{8-[(-pyridin-4-yl-methyl)-amino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-urea
847024-36-6

1-(2-metoxy-5-trifluoromethyl-phenyl)-3-(3-{8-[(-pyridin-4-yl-methyl)-amino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-urea

Conditions
ConditionsYield
In toluene at 20℃; for 0.5h;
2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

4-(2-aminoethyl)-2-nitro-phenylamine
159417-93-3

4-(2-aminoethyl)-2-nitro-phenylamine

C17H17F3N4O4
863910-65-0

C17H17F3N4O4

Conditions
ConditionsYield
In dichloromethane at 20℃; for 2h;
2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

(S)-2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)-phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid
917389-32-3

(S)-2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)-phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: acetonitrile / Reflux
2: acetic acid; palladium diacetate
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / Reflux
4: 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / chlorobenzene / Reflux
5: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / Reflux
6: ethyl acetate / 20 °C
7: sodium hydrogencarbonate; sodium hydroxide; water / tert-butyl methyl ether / Reflux; Large scale
View Scheme
Multi-step reaction with 6 steps
1.1: acetonitrile / 4 h / Reflux; Large scale
2.1: acetic acid; sulfuric acid; sulfur trioxide; palladium diacetate; oxygen / 20 h / 20 °C / Inert atmosphere; Large scale
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 4 h / Reflux; Large scale
4.1: trichlorophosphate / chlorobenzene / 3 h / Reflux; Large scale
4.2: 9 h / Reflux; Large scale
5.1: ethyl acetate / 1 h / 20 °C / Large scale
5.2: 72 h / 20 °C / Large scale
6.1: sodium hydrogencarbonate / water; tert-butyl methyl ether / Large scale
6.2: Reflux; Large scale
View Scheme
Multi-step reaction with 7 steps
1.1: acetonitrile / 7.25 h / 0 °C / Reflux; Large scale
2.1: acetic acid / Inert atmosphere; Large scale
2.2: 20 h / 20 °C / Inert atmosphere; Large scale
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 4 h / 55 °C / Reflux; Large scale
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / chlorobenzene / 12 h / Reflux; Large scale
5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 4 h / Reflux; Large scale
6.1: ethyl acetate / 76 h / 0 - 20 °C / Large scale
7.1: sodium hydrogencarbonate; water; sodium hydroxide / tert-butyl methyl ether / 22 °C / Reflux; Large scale
View Scheme

16588-75-3Downstream Products

16588-75-3Relevant articles and documents

Mediators of hedgehog signaling pathways, compositions and uses related thereto

-

Page/Page column 73, (2015/11/27)

The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.

2-(3-Phenyl-2-piperazinyl-3,4-dihydroquinazolin-4-yl)acetic acids as antiviral agents, especially against cytomegaloviruses

-

, (2008/06/13)

The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, especially for use as anti-viral agents, especially against cytomegalo viruses.

INHIBITION OF p38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS

-

Page/Page column 43, (2010/02/11)

This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.

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