Welcome to LookChem.com Sign In|Join Free

CAS

  • or

166438-88-6

Post Buying Request

166438-88-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

166438-88-6 Usage

General Description

4-(4-Benzylpiperazin-1-yl)Benzaldehyde is a chemical compound with the molecular formula C18H20N2O. It's listed under IUPAC name 4-(4-phenylpiperazin-1-yl)benzaldehyde and belongs to the category of chemical compounds known as benzylpiperazines, which are organic compounds containing a benzyl group attached to a piperazine ring. It's not a widely studied chemical, so available information on its properties, toxicity, or uses is limited. It is primarily used in scientific research as a building block in the synthesis of more complex compounds. 4-(4-BENZYLPIPERAZIN-1-YL)BENZALDEHYDE can also be used in pharmaceutical synthesis and has potential applications in medical research.

Check Digit Verification of cas no

The CAS Registry Mumber 166438-88-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,6,4,3 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 166438-88:
(8*1)+(7*6)+(6*6)+(5*4)+(4*3)+(3*8)+(2*8)+(1*8)=166
166 % 10 = 6
So 166438-88-6 is a valid CAS Registry Number.
InChI:InChI=1/C18H20N2O/c21-15-17-6-8-18(9-7-17)20-12-10-19(11-13-20)14-16-4-2-1-3-5-16/h1-9,15H,10-14H2/p+1

166438-88-6Downstream Products

166438-88-6Relevant articles and documents

Novel benzimidazole-acrylonitrile hybrids and their derivatives: Design, synthesis and antimycobacterial activity

Sirim, Mustafa Mert,Krishna, Vagolu Siva,Sriram, Dharmarajan,Unsal Tan, Oya

, (2020)

This paper reports the synthesis and evaluation of some benzimidazole-acrylonitrile hybrid derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv. Among the derivatives studied, 3b was found to be the most active compound with MIC of 0.78 μg/mL against M. tuberculosis. This is a quite good activity compared with ethambutol (MIC = 1.56 μg/mL). Moreover, 3b showed 2.8 log fold reduction in bacterial count of dormant forms of mycobacterium which is more potent than first line drugs isoniazid, ciprofloxacin, rifampicin and moxifloxacin. Having activities against both active and dormant forms of M. tuberculosis, 3b may be a useful candidate for the development of new drugs to treat tuberculosis.

Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal

Mishra, Chandra Bhushan,Kumari, Shikha,Angeli, Andrea,Bua, Silvia,Buonanno, Martina,Monti, Simona Maria,Tiwari, Manisha,Supuran, Claudiu T.

, p. 430 - 443 (2018/07/25)

We report the design, synthesis and pharmacological assessment of novel benzenesulfonamide derivatives acting as effective carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. All the synthesized compounds were screened for their CA inhibitory action against four isoforms of human origin (h), i.e. hCA I, hCA II, hCA VII and hCA IX. In-vitro carbonic anhydrase inhibition studies have shown that first series, 4-(2-(4-(4-substitutedpiperazin-1-yl)benzylidene)hydrazinyl)benzenesulfonamides (4a- 4i) bestowed low nanomolar range to medium nanomolar range inhibitors against hCA II and hCA VII, effectively involved in epileptogenesis. Furthermore, compounds belonging to the second series, 4-(2-(4-(4-substitutedpiperazin-yl)benzylidene)hydrazinecarbonyl)benzenesulfonamides (8a-8k) showed effective inhibition against hCA VII, being less effective against other hCA isoforms. Inspiring with obtained CA inhibition results, we have chosen some of the potent hCA II and hCA VII inhibitors (4g, 4i and 8d) to test their anti-convulsant efficacy in MES and sc-PTZ seizure tests in Swiss Albino male mice. In result, these compounds significantly attenuated both electrical (MES) as well as chemical (sc-PTZ) induced seizures. Next, in advance anticonvulsant tests, compound 8d displayed long duration of action in time course study and successfully attenuated MES induced seizure in mice up to 6 h after drug administration without showing neurotoxicity in rotarod test. Moreover, this compound was also found to be orally active and effectively abolished generalized tonic-clonic seizures in male Wistar rats upon oral administration, being non-toxic in sub acute toxicity studies.

Design, synthesis, in silico and biological evaluation of novel 2-(4-(4-substituted piperazin-1-yl)benzylidene)hydrazine carboxamides

Kumari, Shikha,Mishra, Chandra Bhushan,Idrees, Danish,Prakash, Amresh,Yadav, Rajesh,Hassan, Md. Imtaiyaz,Tiwari, Manisha

, p. 163 - 174 (2017/02/15)

A series of novel 2-(4-(4-substituted piperazin-1-yl)benzylidene)hydrazinecarboxamide derivatives has been successfully designed and synthesized to evaluate their potential as carbonic anhydrase (CA) inhibitors. The inhibitory potential of synthesized com

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 166438-88-6