166883-20-1 Usage
Description
1-Methyl-2-oxo-5-indolinesulfonyl chloride is a chemical compound with the molecular formula C10H8ClNO3S. It is a sulfonyl chloride derivative of indoline, featuring a chlorine atom and a sulfonyl group attached to the indoline ring. 1-Methyl-2-oxo-5-indolinesulfonyl chloride is recognized for its versatile reactivity and functional group compatibility, making it a valuable building block in the synthesis of various bioactive molecules and pharmaceutical intermediates.
Uses
Used in Organic Synthesis:
1-Methyl-2-oxo-5-indolinesulfonyl chloride is used as a building block in organic synthesis for its ability to form diverse chemical compounds. Its functional group compatibility allows for the creation of a wide range of molecules with potential applications in various fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-Methyl-2-oxo-5-indolinesulfonyl chloride is used as a key intermediate in the development of new drugs. Its reactivity and structural features make it a promising candidate for the synthesis of bioactive molecules with therapeutic potential.
Used in Drug Discovery and Development:
1-Methyl-2-oxo-5-indolinesulfonyl chloride is utilized by researchers and chemists in drug discovery and development due to its potential to contribute to the creation of novel pharmaceuticals. Its unique properties and reactivity are of significant interest in the advancement of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 166883-20-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,6,8,8 and 3 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 166883-20:
(8*1)+(7*6)+(6*6)+(5*8)+(4*8)+(3*3)+(2*2)+(1*0)=171
171 % 10 = 1
So 166883-20-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H8ClNO3S/c1-11-8-3-2-7(15(10,13)14)4-6(8)5-9(11)12/h2-4H,5H2,1H3
166883-20-1Relevant articles and documents
Efficient syntheses of AZD4407 via thioether formation by nucleophilic attack of organometallic species on sulphur
Alcaraz, Marie-Lyne,Atkinson, Stephanie,Cornwall, Philip,Foster, Alison C.,Gill, Duncan M.,Humphries, Lesley A.,Keegan, Philip S.,Kemp, Richard,Merifield, Eric,Nixon, Robert A.,Noble, Allison J.,O'Beirne, Darren,Patel, Zakariya M.,Perkins, Jacob,Rowan, Paul,Sadler, Paul,Singleton, John T.,Tornos, James,Watts, Andrew J.,Woodland, Ian A.
, p. 555 - 569 (2012/12/25)
The development of two efficient strategies for the synthesis of AZD4407 is reported, both of which are considered suitable for large-scale manufacture. In the first approach, 3-bromothiophene is coupled with (2S)-2- methyltetrahydropyran-4-one using Grignard chemistry. Following hydroxyl protection and lithiation at thiophene C-2, reaction with a protected 5-mercapto-1-methyl-1,3-dihydro-indol-2-one derivative bearing a leaving group on sulphur provides AZD4407 after acid-catalysed deprotection and epimerisation. The second approach starts from 2,4-dibromothiophene, which undergoes a selective Grignard exchange reaction at C-2 followed by reaction with similar protected mercapto-oxindole derivatives. Reprotection of the oxindole ring, followed by a second Grignard exchange, and reaction with (2S)-2- methyltetrahydropyran-4-one provides AZD4407 after acid-catalysed deprotection and epimerisation.
