16695-54-8Relevant articles and documents
Preparation of an ABC tricyclic model of the cylindrospermopsin alkaloids via a biomimetically inspired pathway
Evans, Daniel. M.,Horton, Peter N.,Hursthouse, Michael B.,Murphy, Patrick. J.
, p. 20744 - 20751 (2014)
Two tricyclic guanidine model compounds 28 and 29 have been prepared in 12 steps from 1,5-pentanediol using a biomimetic synthetic approach. The pivotal reaction in the sequence is a tethered Biginelli condensation between 21/22 and β-keto esters 23 and 24. This journal is the Partner Organisations 2014.
Eco-friendly access to β-ketoamides: One-step catalyst-and solvent-free amidation of β-ketoesters under microwave irradiation
Dechira, Khadidja,Taleb, Assya,Benmaati, Aouicha,Hacini, Salih,Zahmani, Hadjira Habib
, p. 152 - 160 (2018/03/21)
A highly efficient and facile catalyst- and solvent-free one step amidation of β-ketoesters, without using any additional reagents, is described. Therefore, β-ketoamides are obtained in good to excellent yields by condensation of β-ketoesters with various primary or secondary amines. This eco-friendly protocol has been developed under microwave irradiation.
Addition of Diazo Compounds ipso -C-H Bond to Carbon Disulfide: Synthesis of 1,2,3-Thiadiazoles under Mild Conditions
Zhang, Lei,Sun, Beiqi,Liu, Qianyi,Mo, Fanyang
supporting information, p. 4275 - 4278 (2018/04/14)
We describe here an operationally simple and straightforward synthesis method for a series of diverse 4,5-disubstituted 1,2,3-thiadiazoles via the nucleophilic addition of α-diazo carbonyl compounds to carbon disulfide. This method features using abundant and inexpensive carbon disulfide under mild reaction conditions.
