16699-20-0Relevant articles and documents
Iron-catalyzed synthesis of cinnarizine
Shakhmaev,Sunagatullina, A. Sh.,Zorin
, p. 95 - 97 (2015)
Cinnarizine was synthesized in a high yield by iron-catalyzed cross-coupling of phenylmagnesium chloride with 1-[(2E)-3-chloroprop-2-en-1-yl]-4-(diphenylmethyl)piperazine prepared by allylation of 1-(diphenylmethyl) piperazine with (E)-1,3-dichloropropene.
Oxidative Rearrangement of MIDA (N-Methyliminodiacetic Acid) Boronates: Mechanistic Insights and Synthetic Applications
Kaldas, Sherif J.,Tien, Chieh-Hung,Gomes, Gabriel Dos Passos,Meyer, Stephanie,Sirvinskas, Martynas,Foy, Hayden,Dudding, Travis,Yudin, Andrei K.
supporting information, p. 324 - 328 (2021/01/26)
Herein we report that coordinative hemilability allows the MIDA (N-methyliminodiacetic acid) nitrogen to behave as a nucleophile and intramolecularly intercept palladium π-allyl intermediates. A mechanistic investigation indicates that this rearrangement proceeds through an SN2-like displacement at tetrasubstituted boron to furnish novel DABN boronates. Oxidative addition into the N-C bond of the DABN scaffold furnishes borylated π-allyl intermediates that can then be trapped with a variety of nucleophiles, including in a three-component coupling.
Preparation method and application of adjustable metal organic cage compound for efficiently selective catalytic reduction of nitrobenzaldehyde
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Paragraph 0039-0040, (2019/12/02)
The invention belongs to the technical field of fine chemical engineering. The invention relates to a preparation method and application of an adjustable metal organic cage compound for efficient selective catalytic reduction of nitrobenzaldehyde. According to the preparation method, M in a transition metal salt is used as a node and L is used as a ligand for reaction to prepare the metal organic cage compound, and the synthetic route is as follows: M + L- to M-L; wherein the ligand L is selected from H2FPB; the transition metal salt is selected from one of ferrous perchlorate, cobalttetrafluoroborate, nickel perchlorate or zinc tetrafluoroborate. The metal organic cage compound prepared by the method is low in raw material price and high in yield, and the obtained compound is stable in chemical property and easy to put into practical application. As a target compound M-FPB, the adjustable metal organic cage compound shows that the selectivity of the compound M-FPB can reach 99% in the aspects of reduction of p-nitrobenzaldehyde to prepare p-nitrobenzyl alcohol, one-step synthesis of cinnarizine by reduction catalysis of cinnamyl aldehyde and reduction of p-nitrobenzaldehyde to prepare p-aminobenzaldehyde.
