1670-26-4 Usage
Chemical Properties
Yellowish Waxy Solid
Uses
Different sources of media describe the Uses of 1670-26-4 differently. You can refer to the following data:
1. Involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction.
2. Neurotrophic effects of Sphingosylphosphorylcholine were studied in cerebellar granule neurons of mice and PC-12 cells.
3. Lyso SM (d18:1) has been used: to study its effect on the skeletal muscle ryanodine receptor (RyR1), in the presence and absence of calmodulin through single channel recordings in planar lipid bilayersas an inhibitor of Ca2+ sensor calmodulin (CaM)as a standard in circular dichroism (CD) spectroscopy to determine lipid selectivity of the lipid-peptide interactions
General Description
Lyso SM (d18:1), also known as sphingosylphosphorylcholine (SPC), is a bioactive lipid molecule. This lysophospholipid is present in normal blood plasma, ascites and various tissues.
Biochem/physiol Actions
Sphingosylphosphorylcholine (SPC) is a bioactive lipid that mediates intracellular and extracellular signaling. It mobilizes Ca2+ from intracellular stores via an IP3-independent pathway. It stimulates the production of CCL2 that may contribute to development of atherosclerosis. SPC is a ligand for endothelial differentiation gene receptor 3 (EDG3).
Check Digit Verification of cas no
The CAS Registry Mumber 1670-26-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,7 and 0 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1670-26:
(6*1)+(5*6)+(4*7)+(3*0)+(2*2)+(1*6)=74
74 % 10 = 4
So 1670-26-4 is a valid CAS Registry Number.
InChI:InChI=1/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m0/s1
1670-26-4Relevant articles and documents
An Improved, Versatile, and Easily Scalable Synthesis of Sphingomyelins: Application to Stable Isotope Labeling
Blankenstein, J?rg,Le Strat, Franck,Pérard, Serge,Philippe, Nicolas,Roy, Sébastien
, p. 2106 - 2110 (2020/08/17)
With a view to make conveniently labeled mass spectrometry standards available, a set of deuterated sphingomyelins were prepared by a new expedient, flexible, robust, scalable, and high-yielding synthetic scheme starting from 2-azido-3- O -benzoylsphingos
Process for the preparation of cyclic 4-oxoamidines
-
, (2008/06/13)
The present invention relates to a process for the preparation of cyclic 4-oxoamidines. Such substances are precursors of active substances having biological action. The process according to the invention forms a further method of obtaining this class of compound. By reacting condensation products of aldehydes and aminonitriles or amino acid amides with oxidizing agents, the desired cyclic 4-oxoamidines are obtained according to the invention in good to very good yields.