1670-62-8Relevant articles and documents
Inhibitory effect of HT-1080 tumor cell invasion in vitro using 9-(2'-hydroxyethyl)adenine 2'-phosphates
Kitade, Yukio,Hayashi, Masa-Atsu,Yatome, Chizuko,Chajima, Masamitsu,Nagase, Hisamitsu
, p. 833 - 836 (1997)
Several 9-(2'-hydroxyethyl)purine 2'-phosphates (2a-c and 3) showed a moderate inhibitory effect of tumor cell invasion using Matrigel. These 2'-phosphates (2a-c and 3) also inhibited the activity on type IV collagen degradation by matrix metalloprotease-9.
Regioselective N9 alkylation of purine rings assisted by β-cyclodextrin
Zhang, Qian,Cheng, Gang,Huang, Yong-Zhen,Qu, Gui-Rong,Niu, Hong-Ying,Guo, Hai-Ming
experimental part, p. 7822 - 7826 (2012/09/22)
Under the assistance of β-cyclodextrin, purine was effectively alkylated at N9 together with up to 99% conversion and good to excellent yield using water as the solvent. High regioselectivity-N9/N7 selectivity>99:1 was attributed to the β-cyclodextrin cav
Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder)
Howson, William,Taylor, Edwin Michael,Parsons, Michael Edward,Novelli, Riccardo,Wilczynska, Maria Aleksandra,Harris, Deborah Tracy
, p. 433 - 440 (2007/10/02)
This paper describes studies carried out on a series of ATP analogues on the guinea pig bladder, a tissue reported to possess purinergic P2X-receptors.Optimisation of the pharmacological experimental technique enabled reproducible responses to ATP to be obtained in the 0.2-100 μM concentration range and the potencies of ATP analogues relative to ATP to be accurately determined.Alterations of the three main parts of the ATP molecule, i.e., the triphosphate, ribose and base, suggest that the triphosphate group is responsible for the efficacy of the agonist, whereas the ribose and adenine moieties are associated with affinity. quantitative analysis / ATP / purinergic / P2X-receptors / guinea pig bladder