16728-83-9 Usage
General Description
Methyl(phenyl)amino]acetonitrile is a chemical compound with the molecular formula C9H10N2. It is a colorless liquid with a faint aromatic odor and is used in organic synthesis and pharmaceutical research. It is a versatile building block in the synthesis of various pharmaceutical compounds and is also used as an intermediate in the production of dyes, pigments, and other specialty chemicals. The compound is considered to be moderately toxic and may cause irritation to the skin, eyes, and respiratory system. It is important to handle and store this chemical with care, following proper safety protocols to avoid accidents and exposure.
Check Digit Verification of cas no
The CAS Registry Mumber 16728-83-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,7,2 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 16728-83:
(7*1)+(6*6)+(5*7)+(4*2)+(3*8)+(2*8)+(1*3)=129
129 % 10 = 9
So 16728-83-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H10N2/c1-8-4-2-3-5-9(8)11-7-6-10/h2-5,11H,7H2,1H3
16728-83-9Relevant articles and documents
Cyanoacetic Acid as a Masked Electrophile: Transition-Metal-Free Cyanomethylation of Amines and Carboxylic Acids
Wang, Hongxiang,Shao, Ying,Zheng, Hao,Wang, Hanghang,Cheng, Jiang,Wan, Xiaobing
supporting information, p. 18333 - 18337 (2015/12/24)
Using cyanoacetic acid as a masked electrophile, a new cyanomethylation reaction of amines and carboxylic acids was developed, producing a variety of α-aminonitriles and cyanomethyl esters with good yields and excellent functionality tolerance. This protocol features simple manipulation, inexpensive reagents, and a wide substrate scope. Iodoacetonitrile was generated in situ from the iodination-decarboxylation of cyanoacetic acid in this transformation.
