16728-92-0Relevant articles and documents
RuO4-mediated oxidation of tertiary amines. stereoelectronic effects
Petride, Horia,Florea, Cristina,H?rtopeanu, Anca,Stavarache, Cristina
, p. 89 - 96 (2021/02/05)
Tertiary amines like PhCH2-NMe-CH2R (R = H, Me, CN) underwent RuO4-mediated oxidation by attack at all three N-α-positions. The various reaction products were classified in three groups, according to the functionalized sit
Copper-Catalyzed three- Five- or seven-Component coupling reactions: The selective synthesis of cyanomethylamines, N,N-bis(cyanomethyl)amines and N,N'-bis(cyanomethyl)methylenediamines based on a strecker-type synthesis
Sakai, Norio,Takahashi, Nobuaki,Inoda, Daiki,Ikeda, Reiko,Konakahara, Takeo
, p. 12488 - 12499 (2013/11/06)
We have demonstrated that a cooperative catalytic system comprised of CuCl and Cu(OTf)2 could be used to effectively catalyse the three-, five- and seven-component coupling reactions of aliphatic or aromatic amines, formaldehyde, and trimethylsilyl cyanide (TMSCN), and selectively produce in good yields the corresponding cyanomethylamines, N,N-bis(cyanomethyl)amines and N,N'-bis(cyanomethyl)methylenediamines.