168158-16-5

• 

• Basic information

  1. Product Name: N-[4-(Hydroxyamino)-2(R)-isobutyl-3(S)-methylsuccinyl]-L-2-phenylglycine methylamide
  2. Synonyms: KB-R7785
  3. CAS NO:168158-16-5
  4. Molecular Formula: C₁₈H₂₇N₃O₄
  5. Molecular Weight: 349.43359
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 168158-16-5.mol
  9. Article Data: 1

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: N/A
  5. Density: N/A
  6. Refractive Index: N/A
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. CAS DataBase Reference: N-[4-(Hydroxyamino)-2(R)-isobutyl-3(S)-methylsuccinyl]-L-2-phenylglycine methylamide(CAS DataBase Reference)
  10. NIST Chemistry Reference: N-[4-(Hydroxyamino)-2(R)-isobutyl-3(S)-methylsuccinyl]-L-2-phenylglycine methylamide(168158-16-5)
  11. EPA Substance Registry System: N-[4-(Hydroxyamino)-2(R)-isobutyl-3(S)-methylsuccinyl]-L-2-phenylglycine methylamide(168158-16-5)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 168158-16-5(Hazardous Substances Data)

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• Butanediamide,N1-hydroxy-2-methyl-N4-[(1S)-2-(methylamino)-2-oxo-1-phenylethyl]-3-(2-methylpropyl)-,(2S,3R)- 168158-16-5

  Cas No: 168158-16-5

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• KB-R7785

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• Butanediamide,N1-hydroxy-2-methyl-N4-[(1S)-2-(methylamino)-2-oxo-1-phenylethyl]-3-(2-methylpropyl)-,(2S,3R)-

  Cas No: 168158-16-5

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168158-16-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 168158-16-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,8,1,5 and 8 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 168158-16:
(8*1)+(7*6)+(6*8)+(5*1)+(4*5)+(3*8)+(2*1)+(1*6)=155
155 % 10 = 5
So 168158-16-5 is a valid CAS Registry Number.

168158-16-5Upstream product

• 168158-38-1 (2R,3S)-N⁴-Benzyloxy-2-isobutyl-3-methyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-succinamide 
• 42990-28-3 (R)-2-bromo-4-methylpentanoic acid 
• 188728-97-4 (R)-2,5-Dimethyl-3-[((S)-methylcarbamoyl-phenyl-methyl)-carbamoyl]-hexanoic acid 
• 168158-25-6 2-{(R)-3-Methyl-1-[((S)-methylcarbamoyl-phenyl-methyl)-carbamoyl]-butyl}-malonic acid dibenzyl ester 
• 145660-99-7 2-Benzyloxycarbonyl-3R-isobutyl-succinic acid 4-tert-butyl ester 1-benzyl ester 
• 155947-71-0 benzyl 2<(benzyloxy)carbonyl>-3(R)-(hydroxycarbonyl)-5-methylhexanoate 
• 188729-12-6 (R)-5-Methyl-3-[((S)-methylcarbamoyl-phenyl-methyl)-carbamoyl]-2-methylene-hexanoic acid 
• 130464-88-9 (2R)-2-bromo-4-methylpentanoic acid t-butyl ester 
• 168393-56-4 (2S,3R)-2,5-Dimethyl-3-[((S)-methylcarbamoyl-phenyl-methyl)-carbamoyl]-hexanoic acid 
• 188728-99-6 (2S,3R)-2,5-Dimethyl-3-[((S)-methylcarbamoyl-phenyl-methyl)-carbamoyl]-hexanoic acid tert-butyl ester 
• 168158-22-3 Z-L-phenylglycine methyl amide 
• 135775-09-6 2(R)-[1(S)-(tert-butyloxycarbonyl)ethyl]-4-methylpentanoic acid 
• 170450-78-9 2(R)-Isobutyl-3(S)-methylsuccinic acid 1-<4(S)-(phenylmethyl)-2-oxooxazolidinamide>-4-(tert-butyl ester) 
• 5491-18-9 (S)-N-(benzyloxycarbonyl)phenylglycine 

168158-16-5Downstream Products

168158-16-5Relevant articles and documents

Synthesis and biological evaluation of orally active matrix metaloproteinase inhibitors

Hirayama, Ryoichi,Yamamoto, Minoru,Tsukida, Takahiro,Matsuo, Konomi,Obata, Yuji,Sakamoto, Fumio,Ikedaa, Shoji

, p. 765 - 778 (2007/10/03)

The synthesis and biological evaluation of orally active inhibitors of matrix metalloproteinase are reported. Modifications of the P2' position and the α-substituent of hydroxamic acid derivatives were carried out, and revealed that the P2' substituent influenced the MMP inhibitory activities in vitro and in plasma after oral administration. The hydroxamates with phenylglycine at the P2' position were absorbed well orally. Compound 15e, which exhibited the longest duration of inhibitory activity in plasma after oral administration among the phenylglycine derivatives (5a-5d, 15a, 15c, 15e), was evaluated in a rat adjuvant arthritis model. A reduction in hind foot pad swelling and improvements of some inflammatory parameters were demonstrated when the compound was administered orally. These results indicate the potential of MMP inhibitors for rheumatoid arthritis.

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