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169209-65-8

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169209-65-8 Usage

Uses

MPPG is a potent antagonist of L-AP4-induced effects.

Biological Activity

Potent antagonist of L-AP4-induced effects in rat spinal cord, thalamic and hippocampal neurons, showing selectivity over (1S,3S)-ACPD-induced effects. Potent antagonist of mGlu receptors linked to adenylyl cyclase in adult rat cortical slices.

Check Digit Verification of cas no

The CAS Registry Mumber 169209-65-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,2,0 and 9 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 169209-65:
(8*1)+(7*6)+(6*9)+(5*2)+(4*0)+(3*9)+(2*6)+(1*5)=158
158 % 10 = 8
So 169209-65-8 is a valid CAS Registry Number.

169209-65-8 Well-known Company Product Price

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  • Sigma

  • (M1694)  MPPG  ≥97% (NMR), solid

  • 169209-65-8

  • M1694-10MG

  • 2,047.50CNY

  • Detail
  • Sigma

  • (M1694)  MPPG  ≥97% (NMR), solid

  • 169209-65-8

  • M1694-50MG

  • 8,113.95CNY

  • Detail

169209-65-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-amino-2-(4-phosphonophenyl)propanoic acid

1.2 Other means of identification

Product number -
Other names MPPG

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:169209-65-8 SDS

169209-65-8Downstream Products

169209-65-8Relevant articles and documents

Asymmetric strecker-type reaction of α-aryl ketones. Synthesis of (S)- αM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the antagonists of metabotropic glutamate receptors

Ma, Dawei,Tian, Hongqi,Zou, Guixiang

, p. 120 - 125 (2007/10/03)

Heating a mixture of α-aryl ketone with (R)-phenylglycinol produces a mixture of imine and 1,3-dioxazolidine. Treatment of this mixture with trimethylsilyl cyanide followed by transformation of nitrile to ester gives Strecker-type reaction products. The diastereoselectivity of the generated α-amino esters is from 2/1 to 7/1, and the (R,S)isomer is found as the major product. The (R,S) and (R,R)isomers can be separated by conversion to their N-Cbz or cyclization derivatives. Using this methodology, four antagonists of metabotropic glutamate receptors, (S)-αM4CPG, (S)-MPPG, (S)AIDA, and (S)- APICA, are synthesized.

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