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1694-57-1

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1694-57-1 Usage

General Description

2-(2-Chlorobenzoyl)pyridine is a chemical compound that consists of a pyridine ring with a substituted chlorobenzoyl group attached to the second position. 2-(2-CHLOROBENZOYL)PYRIDINE is often used in organic synthesis as a building block for heterocyclic compounds and pharmaceuticals. It is also used as a starting material for the preparation of various bioactive compounds and as an intermediate in the production of agrochemicals. Additionally, 2-(2-Chlorobenzoyl)pyridine may have potential applications in the development of new materials and chemical processes. However, it is important to handle this compound with care, as it may be harmful if ingested or inhaled, and can cause skin and eye irritation upon contact.

Check Digit Verification of cas no

The CAS Registry Mumber 1694-57-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,9 and 4 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1694-57:
(6*1)+(5*6)+(4*9)+(3*4)+(2*5)+(1*7)=101
101 % 10 = 1
So 1694-57-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H8ClNO/c13-10-6-2-1-5-9(10)12(15)11-7-3-4-8-14-11/h1-8H

1694-57-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (2-chlorophenyl)-pyridin-2-ylmethanone

1.2 Other means of identification

Product number -
Other names 2-o-chlorobenzoylpyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1694-57-1 SDS

1694-57-1Relevant articles and documents

Kinetic Energy Release and Position of Transition State During the Intramolecular Substitution of Ionized 2-Benzoyl Pyridines

Schubert, Ralf,Gruetzmacher, Hans-Friedrich

, p. 122 - 130 (1980)

The loss of substituents X from molecular ions of ortho substituted 2-benzoyl pyridines has been investigated as a function of the dissociation energy of the C-X bond.Comparison of unimolecular and collisional induced decompositions of the resulting + ions and reference ions arising from 3-hydroxypyridoindole shows that cyclic fragment ions are formed in every case by an intramolecular substitution reaction with the exception of the parent compound (X=H), which gives rise to a mixture of + ions with different structures.The heat of formation of the cyclic ion has been estimated experimentally and by calculation using thermochemical data, and from this value and the appearance energies, the activation energies of the reverse reactions have been evaluated for the different reaction systems.Measurement of the kinetic energy release during the substitution reactions shows that only part of the reverse activation energy is released as kinetic energy.The energy partitioning quotient varies from 0.37 to 0.08 depending on the dissociation energy of the C-X bond or the reaction enthalpy.A sudden change in the energy partitioning quotient is observed with increasing exothermicity of the reaction, paralleling the behaviour of similar reaction systems.These results are interpreted as a demonstration of the influence of the variation of transition state position on the energy partitioning quotient.

Ortho-halogenated phenylpyridine ketone compound and preparation method thereof

-

Paragraph 0110-0113, (2019/12/25)

The invention relates to an ortho-halogenated phenylpyridine ketone compound and a preparation method thereof. According to the invention, dibromohydantoin or dichlorohydantoin is taken as a halogenating reagent, and the ortho-halogenation of a diarylketo

Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT

Deane, Karen J.,Summers, Robert L.,Lehane, Adele M.,Martin, Rowena E.,Barrow, Russell A.

supporting information, p. 576 - 581 (2014/06/09)

The emergence and spread of malaria parasites that are resistant to chloroquine (CQ) has been a disaster for world health. The antihistamine chlorpheniramine (CP) partially resensitizes CQ-resistant (CQR) parasites to CQ but possesses little intrinsic antiplasmodial activity. Mutations in the parasite's CQ resistance transporter (PfCRT) confer resistance to CQ by enabling the protein to transport the drug away from its site of action, and it is thought that resistance-reversers such as CP exert their effect by blocking this CQ transport activity. Here, a series of new structural analogues and homologues of CP have been synthesized. We show that these compounds (along with other in vitro CQ resistance-reversers) inhibit the transport of CQ via a resistance-conferring form of PfCRT expressed in Xenopus laevis oocytes. Furthermore, the level of PfCRT-inhibition was found to correlate well with both the restoration of CQ accumulation and the level of CQ resensitization in CQR parasites.

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