169870-82-0Relevant articles and documents
Preparation method of racemic D/L-tert-leucine
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Paragraph 0044-0046, (2020/06/20)
The invention discloses a preparation method of racemic D/L-tert-leucine, and belongs to the technical field of organic synthesis. Tert-butylpyruvic acid is used as a raw material, and racemic D/L-tert-leucine is obtained through a two-step reaction, wherein in the first step, a Schiff base is generated through a condensation reaction with NH2-P and in the second step, the Schiff base is reduced,deprotection is carried out by using an acid, and the base is adjusted to an isoelectric point to obtain the racemic D/L-tert-leucine. The method is simple and convenient to operate and high in reaction yield, and the purity of the obtained raceme can reach 99% or above.
PROCESS FOR PRODUCTION OF N-ALKOXYCARBONYL-tert-LEUCINES
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Page/Page column 14, (2012/03/26)
A high quality N-alcoxycarbonyl-tert leucine can be efficiently and stably produced with an easy procedure by reacting tert-leucine with an N-alcoxycarbonylating agent in the presence of water, wherein the use amount of the N-alcoxycarbonylating agent is not less than 0.90 times by mole and not more than 1.00 times by mole relative to the tert-leucine, with maintaining the pH of the reaction mixture in the range of not less than 9 and not more than 13 using a basic agent. In addition, an N-alcoxycarbonyl-tert-leucine can be efficiently extracted from the basic aqueous solution thereof under a mild condition using a water-immiscible solvent by mixing a hydroxide. Furthermore, the two crystal forms of N-butoxycarbonyl-tert-leucine can be controlled by adjusting the water amount in crystallization step, and the compound can be stably produced in an industrial production.
Potassium channel openers
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, (2008/06/13)
Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
