170277-77-7

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• Basic information

  1. Product Name: (3S)-3-[2-(MESYLOXY)ETHOXY]-4-(TRITYLOXY)BUTYL METHANESULFONATE
  2. Synonyms: (3S)-3-[2-(MESYLOXY)ETHOXY]-4-(TRITYLOXY)BUTYL METHANESULFONATE;PKC INHIBITOR-BIS-MESYLATE LINKER;S-3-(2-hydroxy)ethoxy-4-trityloxybutan-1-ol;(S)-2-((4-((methylsulfonyl)oxy)-1-(trityloxy)butan-2-yl)oxy)ethyl methanesulfonate
  3. CAS NO:170277-77-7
  4. Molecular Formula: C₂₇H₃₂O₈S₂
  5. Molecular Weight: 548.67
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 170277-77-7.mol
  9. Article Data: 6

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 721.7±60.0 °C(Predicted)
  3. Flash Point: N/A
  4. Appearance: /
  5. Density: 1.267±0.06 g/cm3(Predicted)
  6. Refractive Index: N/A
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. CAS DataBase Reference: (3S)-3-[2-(MESYLOXY)ETHOXY]-4-(TRITYLOXY)BUTYL METHANESULFONATE(CAS DataBase Reference)
  10. NIST Chemistry Reference: (3S)-3-[2-(MESYLOXY)ETHOXY]-4-(TRITYLOXY)BUTYL METHANESULFONATE(170277-77-7)
  11. EPA Substance Registry System: (3S)-3-[2-(MESYLOXY)ETHOXY]-4-(TRITYLOXY)BUTYL METHANESULFONATE(170277-77-7)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 170277-77-7(Hazardous Substances Data)

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• SDS
• Upstream product
• Downstream Products
• Article

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• 1-Butanol,3-[2-[(methylsulfonyl)oxy]ethoxy]-4-(triphenylmethoxy)-, 1-methanesulfonate,(3S)-

  Cas No: 170277-77-7

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• Henan Tianfu Chemical Co., Ltd.
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• (3S)-3-{2-[(METHYLSULFONYL)OXY]ETHOXY}-4-(TRITYLOXY)BUTYL METHANESULFONATECAS

  Cas No: 170277-77-7

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• Hangzhou Fandachem Co.,Ltd
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170277-77-7 Usage

General Description

(3S)-3-[2-(mesyloxy)ethoxy]-4-(trityloxy)butyl methanesulfonate is a chemical compound with the molecular formula C29H36O7S. It is a sulfonate ester that is commonly used as a protecting group for alcohols in organic synthesis. The mesyl (CH3SO2) and trityl (C6H5C(CH2O)3) groups are used to temporarily mask the hydroxyl groups in organic compounds, allowing for selective reactions to occur without interference from the hydroxyl groups. (3S)-3-[2-(MESYLOXY)ETHOXY]-4-(TRITYLOXY)BUTYL METHANESULFONATE is often used in the synthesis of complex organic molecules, particularly in the pharmaceutical and agrochemical industries. It is important to handle this compound with care, as it is a potential irritant to the skin, eyes, and respiratory system, and may also be harmful if ingested or inhaled.

Check Digit Verification of cas no

The CAS Registry Mumber 170277-77-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,0,2,7 and 7 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 170277-77:
(8*1)+(7*7)+(6*0)+(5*2)+(4*7)+(3*7)+(2*7)+(1*7)=137
137 % 10 = 7
So 170277-77-7 is a valid CAS Registry Number.

170277-77-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	[(3S)-3-(2-methylsulfonyloxyethoxy)-4-trityloxybutyl] methanesulfonate

1.2 Other means of identification

Product number	-
Other names	1-Butanol,3-[2-[(methylsulfonyl)oxy]ethoxy]-4-(triphenylmethoxy)-,methanesulfonate,(3S)-(9CI)

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:170277-77-7 SDS

170277-77-7Upstream product

• 124-63-0 methanesulfonyl chloride 
• 170277-79-9 (3S)-3-(2-hydroxyethoxy)-4-(triphenylmethoxy)-1-butanol 
• 76-83-5 trityl chloride 
• 42757-04-0 ethyl 3,6-dihydro-2H-pyran-2-carboxylate 
• 172323-66-9 (S)-(-)-(3,6-Dihydro-2H-pyran-2-yl)methanol 
• 170277-78-8 1,1',1''-[[[(2S)-4-methyl-2-(2-propen-1-yloxy)-4-penten-1-yl]-oxy]methylidyne]trisbenzene 
• 170277-82-4 (2S)-1-triphenylmethoxy-4-pentene-2-ol 
• 203250-06-0 (R)-3-chloro-1-O-trityl-1,2-propanediol 
• 129940-50-7 (S)-tritylglycidol 

170277-77-7Downstream Products

• 170277-74-4 (9S)-6,7,10,11-tetrahydro-19-methyl-9-[(triphenylmethoxy)-methyl]-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h]-[1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione 
• 203250-04-8 (S)-4-(triphenylmethoxy)-2-(2-chloroethoxy)-1-chlorobutane 
• 203250-05-9 (S)-4-(triphenylmethoxy)-2-(2-iodoethoxy)-1-iodobutane 

170277-77-7Relevant articles and documents

Hetero Diels - Alder-biocatalysis approach for the synthesis of (S)-3-[2-{(methylsulfonyl)oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol methanesulfonate, a key intermediate for the synthesis of the PKC inhibitor LY333531

Caille, Jean-Claude,Govindan,Junga, Heiko,Lalonde, Jim,Yao, Yiming

, p. 471 - 476 (2002)

A cost-effective and easily scaled-up process has been developed for the synthesis of (S)-3-[2-{(methylsulfonyl)oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol methanesulfonate, a key intermediate used in the synthesis of a protein kinase C inhibitor drug through a combination of hetero Diels - Alder and biocatalytic reactions. The Diels - Alder reaction between ethyl glyoxylate and bntadiene was used to make racemic 2-ethoxy-carbonyl-3,6-dihydro-2H-pyran. Treatment of the racemic ester with Bacillus lentus protease resulted in the selective hydrolysis of the R-enantiomer and yielded S-2-ethoxycarbonyl-3,6-dihydro-2H-pyran in excellent optical purity, which was reduced to S-3,6-dihdro-2H-pyran-2-yl methanol. Tritylation of this alcohol, followed by reductive ozonolysis and mesylation afforded the product in 10-15% overall yield and with >99% ee and chemical purity. Details of the process development work done on each step are given.

Process for producing butanetriol derivative

-

, (2008/06/13)

A process for preparing a butanetriol derivative of the formula (1) useful as intermediates of medicines wherein R1is the same defined below, which comprises reacting a compound of the formula (3) wherein R1and R2are the different protecting groups, and an ethylene glycol derivative in a basic condition to prepare a compound of the formula (4) or (4a) wherein R1and R2are the same defined above, and then subjecting the compound (4) or (4a) to selective deprotection reaction.

PROTEIN KINASE C INHIBITOR

-

, (2008/06/13)

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