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172733-78-7

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172733-78-7 Usage

Description

4-(ACETYLAMINO)-1-BENZYL-4-PHENYLPIPERIDINE is a complex chemical compound featuring an acetylamino group, a benzyl group, and a phenyl group attached to a piperidine ring. It is recognized for its versatility in organic chemistry and its role as a precursor in the synthesis of pharmaceutical drugs.

Uses

Used in Pharmaceutical Industry:
4-(ACETYLAMINO)-1-BENZYL-4-PHENYLPIPERIDINE is used as a chemical precursor for the synthesis of various pharmaceutical drugs, particularly analgesics and anesthetics, due to its unique molecular structure that allows for the creation of diverse molecules with different biological activities.
Used in Substance Abuse Treatment:
4-(ACETYLAMINO)-1-BENZYL-4-PHENYLPIPERIDINE is studied for its potential application in treating substance abuse disorders, leveraging its chemical properties to contribute to therapeutic interventions for addiction recovery.
Used in Neurological Condition Treatment:
4-(ACETYLAMINO)-1-BENZYL-4-PHENYLPIPERIDINE is also being investigated for its possible role in addressing neurological conditions, suggesting its capacity to interact with neurological pathways and mechanisms, thereby offering potential therapeutic benefits for such conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 172733-78-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,2,7,3 and 3 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 172733-78:
(8*1)+(7*7)+(6*2)+(5*7)+(4*3)+(3*3)+(2*7)+(1*8)=147
147 % 10 = 7
So 172733-78-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H24N2O/c1-17(23)21-20(19-10-6-3-7-11-19)12-14-22(15-13-20)16-18-8-4-2-5-9-18/h2-11H,12-16H2,1H3,(H,21,23)

172733-78-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(1-benzyl-4-phenylpiperidin-4-yl)acetamide

1.2 Other means of identification

Product number -
Other names 4-Acetamido-1-benzyl-4-phenylpiperidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:172733-78-7 SDS

172733-78-7Relevant articles and documents

Structure-guided design and synthesis of P1′ position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors

Tagad, Harichandra D.,Hamada, Yoshio,Nguyen, Jeffrey-Tri,Hidaka, Koushi,Hamada, Takashi,Sohma, Youhei,Kimura, Tooru,Kiso, Yoshiaki

, p. 5238 - 5246 (2011/10/08)

Previously, we reported potent pentapeptidic BACE1 inhibitors with the hydroxymethylcarbonyl isostere as a substrate transition-state mimic. To improve the in vitro potency, we further reported pentapeptidic inhibitors with carboxylic acid bioisosteres at the P4 and P1′ positions. In the current study, we screened new P1′ position 1-phenylcycloalkylamine analogs to find non-acidic inhibitors that possess double-digit nanomolar range IC50 values. An extensive structure-activity relationship study was performed with various amine derivatives at the P1′ position. The most potent inhibitor of this pentapeptide series, KMI-1830, possessing 1-phenylcyclopentylamine at the P 1′ position had an IC50 value of 11.6 nM against BACE1 in vitro enzymatic assay.

(3R)-3-Amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Nitta, Aiko,Fujii, Hideaki,Sakami, Satoshi,Nishimura, Yutaka,Ohyama, Tomofumi,Satoh, Mikiya,Nakaki, Junko,Satoh, Shiho,Inada, Chifumi,Kozono, Hideki,Kumagai, Hiroki,Shimamura, Masahiro,Fukazawa, Tominaga,Kawai, Hideki

scheme or table, p. 5435 - 5438 (2009/05/30)

Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides and 3-amino-N-(4-aryltetrahydropyran-4-yl)butanamides were synthesized and evaluated as dipeptidyl peptidase IV (DPP-IV) inhibitors. Derivatives incorporating the 6-substituted benzothiazole group showed highly potent DPP-IV inhibitory activity. Oral administration of (3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide (12u) reduced blood glucose excursion in an oral glucose tolerance test.

A reliable and efficient synthesis of SR 142801

Giardina,Grugni, Mario,Rigolio, Roberto,Vassallo, Marco,Erhard, Karl,Farina, Carlo

, p. 2307 - 2310 (2007/10/03)

A convenient synthesis of the potent human NK-3 receptor antagonist SR 142801, (S)-(+)-N-{{3-[1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]prop-1 -yl}-4-phenylpiperidin-4-yl}-N-methylacetamide [(S)-(+)-(15)], is described. Improvements over the previously reported procedure are the preparation of the intermediate 5 via the novel imide 3 and subsequent reaction with the nucleophile 14, which reacts, regioselectively, at the endocyclic nitrogen.

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