17297-82-4 Usage
Originator
Pervetral, Homburg , W. Germany ,1962
Manufacturing Process
32 parts of 10-(γ-N-piperazinopropyl)-4-azaphenthiazine in 200 cc of butanol
with 9 parts of ethylene chlorohydrin and 14 parts of finely powdered potash are heated for 4 hours under reflux while stirring vigorously. After cooling, extraction is carried out with dilute hydrochloric acid, the substance is finally washed with water and the combined hydrochloric acid aqueous phase is washed twice with ether. The base is then liberated with concentrated sodium hydroxide solution and taken up in chloroform. The chloroform solution is dried with potash and concentrated by evaporation. 26.4 parts of (10-γ-N-Bhydroxyethylpiperazino-N1-propyl)-4-azaphenthiazine are distilled over at 280°C to 300°C/6 mm. The dihydrochloride is obtained in isopropanol with isopropanolic hydrochloric acid. The product melts at 218°C to 220°C.
Therapeutic Function
Antiemetic
Safety Profile
A poison by intravenous, intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NOx, SOx, and Cl-.
Check Digit Verification of cas no
The CAS Registry Mumber 17297-82-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,2,9 and 7 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 17297-82:
(7*1)+(6*7)+(5*2)+(4*9)+(3*7)+(2*8)+(1*2)=134
134 % 10 = 4
So 17297-82-4 is a valid CAS Registry Number.
InChI:InChI=1/C20H26N4OS.2ClH/c25-16-15-23-13-11-22(12-14-23)9-4-10-24-17-5-1-2-6-18(17)26-19-7-3-8-21-20(19)24;;/h1-3,5-8,25H,4,9-16H2;2*1H