1737-06-0 Usage
Description
4'-(Trifluoromethoxy)acetanilide, an acetanilide derivative with the molecular formula C9H8F3NO2, features a trifluoromethoxy group attached to the para position of the phenyl ring. This chemical compound is recognized for its versatile applications in organic synthesis, pharmaceutical drug preparation, and as a reagent in chemical reactions, as well as a building block for synthesizing other organic compounds. Its potential biological and pharmacological activities further establish its importance in scientific and industrial applications.
Uses
Used in Organic Synthesis:
4'-(Trifluoromethoxy)acetanilide is used as an intermediate in organic synthesis for the preparation of various organic compounds. Its unique structure allows for the formation of new chemical entities with potential applications in different fields.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4'-(Trifluoromethoxy)acetanilide is utilized for the preparation of various pharmaceutical drugs. Its presence in drug molecules can contribute to improved pharmacological properties, such as enhanced solubility, stability, and bioavailability.
Used as a Reagent in Chemical Reactions:
4'-(Trifluoromethoxy)acetanilide serves as a reagent in chemical reactions, facilitating the synthesis of complex organic molecules. Its reactivity and selectivity make it a valuable tool in the development of novel chemical processes.
Used as a Building Block for Synthesis of Other Organic Compounds:
4'-(TRIFLUOROMETHOXY)ACETANILIDE is also used as a building block for the synthesis of other organic compounds, enabling the creation of a diverse range of chemical structures with potential applications in various industries.
Used in Scientific Research:
4'-(Trifluoromethoxy)acetanilide has been studied for its potential biological and pharmacological activities, making it a valuable subject of scientific research. Its exploration in this context can lead to the discovery of new therapeutic agents and a deeper understanding of its properties and interactions.
Used in Industrial Applications:
4'-(TRIFLUOROMETHOXY)ACETANILIDE's versatility and importance in various scientific applications extend to industrial uses, where it can contribute to the development of new products and processes across different sectors.
Check Digit Verification of cas no
The CAS Registry Mumber 1737-06-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,3 and 7 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1737-06:
(6*1)+(5*7)+(4*3)+(3*7)+(2*0)+(1*6)=80
80 % 10 = 0
So 1737-06-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H8F3NO2/c1-6(14)13-7-2-4-8(5-3-7)15-9(10,11)12/h2-5H,1H3,(H,13,14)
1737-06-0Relevant articles and documents
Copper-promoted difunctionalization of unactivated alkenes with silanes
Chen, Xiaoyu,Guo, Zhuangzhuang,Li, Jingya,Wu, Yangjie,Wu, Yusheng,Xue, Yingying,Zou, Dapeng
supporting information, p. 989 - 994 (2022/02/11)
An efficient copper-catalyzed cascade difunctionalization of N-allyl anilines toward the synthesis of silylated indolines using commercially available silanes has been reported. This strategy provides a new avenue for the synthesis of a diverse array of i
An Environmentally Benign, Catalyst-Free N?C Bond Cleavage/Formation of Primary, Secondary, and Tertiary Unactivated Amides
Kumar, Vishal,Dhawan, Sanjeev,Girase, Pankaj Sanjay,Singh, Parvesh,Karpoormath, Rajshekhar
, p. 5627 - 5639 (2021/11/11)
Herein, we report an operationally simple, cheap, and catalyst-free method for the transamidation of a diverse range of unactivated amides furnishing the desired products in excellent yields. This protocol is environmentally friendly and operates under extremely mild conditions without using any promoter or additives. Significantly, this strategy has been implied in the chemoselective synthesis of a pharmaceutical molecule, paracetamol, on a gram-scale with excellent yield. We anticipate that this universally applicable strategy will be of great interest in drug discovery, biochemistry, and organic synthesis.
TRIFLUOROMETHOXYLATION OF ARENES VIA INTRAMOLECULAR TRIFLUOROMETHOXY GROUP MIGRATION
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Page/Page column 100, (2016/05/02)
The present invention provides a process of producing a trifluoromethoxylated aryl or trifluoromethoxylated heteroaryl having the structure: (I), wherein A is an aryl or heteroaryl, each with or without subsutitution; and R1 is -H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), - (alkylaryl), - (alkylheteroaryl), -NH-(alkyl), -N(alkyl)2, -NH-(alkenyl), -NH-(alkynyl) -NH-(aryl), -NH-(heteroaryl), -O-(alkyl), -O-(alkenyl), -O-(alkynyl), -O-(aryl), -O-(heteroaryl), -S-(alkyl), -S- (alkenyl), -S-(alkynyl), -S-(aryl), or -S-(heteroaryl), comprising: (a) reacting a compound having the structure: (II), with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: (III); and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure: (I).
