174072-26-5 Usage
General Description
2-(4-Amino-phenyl)-3-[(benzyl-methyl-amino)-methyl]-7-(2,6-difluoro-benzyl)-5-isobutyryl-7H-thieno[2,3-b]pyridin-4-one, also known as TDPU-332, is a synthetic chemical compound with potential pharmaceutical applications. It is a thieno[2,3-b]pyridin-4-one derivative that has been studied for its potential as a calcium channel blocker and potential treatment for cardiovascular diseases. It has also been investigated for its potential anti-inflammatory and anti-tumor properties. 2-(4-Amino-phenyl)-3-[(benzyl-methyl-amino)-methyl]-7-(2,6-difluoro-benzyl)-5-isobutyryl-7H-thieno[2,3-b]pyridin-4-one is currently being researched for its potential therapeutic uses, particularly in the treatment of various diseases and medical conditions. However, further research and clinical trials are required to determine its safety and efficacy for human use.
Check Digit Verification of cas no
The CAS Registry Mumber 174072-26-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,0,7 and 2 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 174072-26:
(8*1)+(7*7)+(6*4)+(5*0)+(4*7)+(3*2)+(2*2)+(1*6)=125
125 % 10 = 5
So 174072-26-5 is a valid CAS Registry Number.
InChI:InChI=1/C33H31F2N3O2S/c1-20(2)30(39)26-19-38(18-24-27(34)10-7-11-28(24)35)33-29(31(26)40)25(17-37(3)16-21-8-5-4-6-9-21)32(41-33)22-12-14-23(36)15-13-22/h4-15,19-20H,16-18,36H2,1-3H3
174072-26-5Relevant articles and documents
Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists
Imada, Takashi,Cho, Nobuo,Imaeda, Toshihiro,Hayase, Yoji,Sasaki, Satoshi,Kasai, Shizuo,Harada, Masataka,Matsumoto, Hirokazu,Endo, Satoshi,Suzuki, Nobuhiro,Furuya, Shuichi
, p. 3809 - 3825 (2007/10/03)
Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one-based non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonists are described. Starting with the thienopyridin-4-one derivative 26d (T-98475) an optimization study was performed, which resulted in the identification of a highly potent and orally bioavailable LHRH receptor antagonist, 3-(N-benzyl-N-methylaminomethyl)-7-(2,6- difluorobenzyl)-4,7-dihydro-2-[4-(1-hydroxy-1-cyclopropanecarboxamido)phen-yl] -5-isobutyryl-4-oxothieno[2,3-b]pyridine (33c). Compound 33c displayed subnanomolar in vitro activities for the human receptor and its oral administration caused effective suppression of the plasma LH levels in castrated male cynomolgus monkeys. Furthermore, SAR studies revealed that a hydroxyalkylamido moiety on the 2-phenyl ring is virtually equivalent to an alkylureido moiety, at least in this series of compounds.
Condensed-ring thiophene derivatives, their production and use
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, (2008/06/13)
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