177760-52-0Relevant articles and documents
NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1
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Page/Page column 172-173, (2020/12/11)
An object of the invention is to provide compounds as selective JAK1 inhibitor, a process for preparation of the inhibitors, a composition containing the compounds and utility of the compounds.
ANTIBACTERIAL THERAPEUTICS AND PROPHYLACTICS
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Paragraph 00382, (2017/02/24)
The present disclosure relates generally to novel molecules, compositions, and formulations for treatment of bacterial infections in general and more specifically to bacterial infections with antibiotic resistant pathogens.
Tuning and predicting biological affinity: Aryl nitriles as cysteine protease inhibitors
Ehmke, Veronika,Quinsaat, Jose Enrico Q.,Rivera-Fuentes, Pablo,Heindl, Cornelia,Freymond, Céline,Rottmann, Matthias,Brun, Reto,Schirmeister, Tanja,Diederich, Fran?ois
supporting information; experimental part, p. 5764 - 5768 (2012/08/28)
A series of aryl nitrile-based ligands were prepared to investigate the effect of their electrophilicity on the affinity against the cysteine proteases rhodesain and human cathepsin L. Density functional theory calculations provided relative reactivities of the nitriles, enabling prediction of their biological affinity and cytotoxicity and a clear structure-activity relationship.
