178209-28-4 Usage
Description
6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-3-amine, also known as THP, is a bicyclic organic compound belonging to the class of heterocyclic amines. It features a seven-membered ring structure with a nitrogen atom, making it a valuable compound in medicinal chemistry due to its pharmacological and therapeutic properties.
Uses
Used in Pharmaceutical Synthesis:
6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-3-amine is used as a key intermediate in the synthesis of various pharmaceuticals, including antimalarial and anticancer drugs. Its unique structure allows for the development of new therapeutic agents targeting specific diseases.
Used in Neuromodulation Research:
In the field of neuroscience, 6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-3-amine is used as a research compound for its potential as a neuromodulator. It has been investigated for its ability to modulate neurotransmitter release, which could lead to advancements in the understanding and treatment of neurological disorders.
Used in Medicinal Chemistry:
6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-3-amine is utilized in medicinal chemistry for its promising pharmacological properties. Its unique structure and potential applications make it a valuable compound for the development of new drugs and therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 178209-28-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,8,2,0 and 9 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 178209-28:
(8*1)+(7*7)+(6*8)+(5*2)+(4*0)+(3*9)+(2*2)+(1*8)=154
154 % 10 = 4
So 178209-28-4 is a valid CAS Registry Number.
178209-28-4Relevant articles and documents
Synthesis and structure-activity relationships of fused imidazopyridines: A new series of benzodiazepine receptor ligands
Takada, Susumu,Sasatani, Takashi,Chomei, Nobuo,Adachi, Makoto,Fujishita, Toshio,Eigyo, Masami,Murata, Shunji,Kawasaki, Kazuo,Matsushita, Akira
, p. 2844 - 2851 (2007/10/03)
2-Arylimidazo[4,5-c]quinolines and analogous fused imidazopyridines were synthesized and evaluated as benzodiazepine receptor ligands. Affinity to the receptors was greatly affected by the bulkiness of the aryl group at the 2- position, compared to the pyrazoloquinolines such as CGS-9896. Derivatives with an isoxazole moiety at the 2-position showed high binding affinity and in vivo activity. In the imidazo[4,5-c]quinoline series, substitution at the 6-position decreased or abolished activity. Most derivatives with an unsubstituted isoxazolyl group showed antagonist or inverse agonist activity except for the 7-halo analogues, which exhibited agonist activity. On the other hand, 5-methylisoxazol-3-yl or 3-methylisoxazol-5-yl derivatives generally exhibited agonist activity. A similar substitution effect on the isoxazole moiety was observed in the imidazopyridines fused with a nonaromatic ring. From the detailed pharmacological evaluation, S-8510, 2- (3-isoxazolyl)-3,6,7,9-tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine monophosphate, possessing weak inverse agonist activity was selected as a therapeutic candidate for the treatment of some symptoms of senile dementia.
