179250-28-3Relevant articles and documents
(2-benzylphenyl)piperazine derivatives and use thereof
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Paragraph 0142; 0148; 0149; 0150; 0151, (2019/11/19)
The invention discloses (2-benzylphenyl)piperazine derivatives, a use thereof, and a medicinal composition comprising above compounds. The derivatives and the medicinal composition are used for inhibiting serotonin reuptake. The invention also relates to
Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands
Marinkovic, Dragan,Tucci, Fabio C.,Tran, Joe A.,Fleck, Beth A.,Wen, Jenny,Chen, Chen
scheme or table, p. 4817 - 4822 (2009/05/26)
A series of piperazinebenzylalcohols were prepared and studied to compare with their ketone and amine analogs as MC4R antagonists. Several benzylalcohols such as 14a and 14g displayed low nanomolar binding affinities (Ki 10 nM), and high sele
Aryl piperazine melanocortin MC4 receptor agonists
Dyck, Brian,Parker, Jessica,Phillips, Teresa,Carter, Lee,Murphy, Brian,Summers, Robin,Hermann, Julia,Baker, Tracy,Cismowski, Mary,Saunders, John,Goodfellow, Val
, p. 3793 - 3796 (2007/10/03)
Incorporation of substituted phenyl piperazine privileged structures into a known MC4 specific dipeptoid consensus sequence resulted in a series of potent (EC50=24 nM) and selective MC4-R agonists. We report the SAR of this series of compounds