180287-02-9Relevant articles and documents
Fluorination of methyl 3-oxopentanoate (MOP) using difluorobis(fluoroxy)methane, BDM
Bailey III, Wade H.,Casteel Jr., William J.,Syvret, Robert G.
, p. 1416 - 1420 (2002)
Difluorobis(fluoroxy)methane, BDM, is an electrophilic fluorinating agent that is capable of affecting selective monofluorination of 1,3-dicarbonyls such as diketones and ketoesters with very high regioselectivity. For example, in highly acidic anhydrous HF (AHF) solvent, fluorination of methyl 3-oxopentanoate (MOP) with BDM provides methyl 2-fluoro-3-oxopentanoate (MFOP) with 100% conversion and 95% selectivity. In mixtures of HF and methanol, fluorination conversions and selectivity are markedly lower. In comparison, direct fluorination of MOP with dilute F2 typically affords a fluorinated product that is less pure, being contaminated with radical fluorination byproducts that are difficult to separate. Fluorination of MOP with dilute mixtures of BDM and F2 is generally more selective than using dilute F2 alone.
Novel bi-cyclic or tri-cyclic heterocyclic compound
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Paragraph 5047 - 5049, (2016/10/07)
The present invention provides novel bi-cyclic or tri-cyclic compound represented by formula (I) or pharmaceutical acceptable salt thereof, [wherein, ring A is an aromatic group which may be substituted, one of X1 and X2 is a carbon atom, and another is a nitrogen atom, X3 is a nitrogen atom or CR2, X4 is a nitrogen atom or CR3, X5 is a sulfur atom or -CH=CH-, Z1 is an oxygen atom, -C(R6)(R7)-, -NH-, -C(R6)(R7)-NH-, -NH-C(R6)(R7)-, -C(R6)(R7)-O-, -O-C(R6)(R7)- or a single bone, one of Z2 and Z3 is CH and another one is a nitrogen atom, or both are nitrogen atoms, the other symbols are same as those defined in the specification.]
An original synthesis of highly ordered organosilica with a high content of thiol groups
Alauzun, Johan,Mehdi, Ahmad,Reye, Catherine,Corriu, Robert J. P.
, p. 347 - 349 (2008/02/08)
Well ordered bridged organosilica highly functionalised with disulfide groups were obtained by self-assembly of α,ω-bis(trimethoxysilyl) alkyldisulfide under hydrophilic conditions; the reduction of disulfide cores to SH groups gave rise to material having a high mercury ion adsorption capacity. The Royal Society of Chemistry 2006.
PROCESS FOR PRODUCING 2-FLUORO-3-OXOALKYLCARBOXYLIC ACID ESTER
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Page/Page column 6-8, (2008/06/13)
A process for producing a 2-fluoro-3-oxoalkylcarboxylic acid ester by fluorinating 3-oxoalkylcarboxylic acid ester with a fluorine gas is provided. The process is characterized in that the concentration of 3-oxoalkylcarboxylic acid ester in the reaction mixture for fluorination is maintained at 3wt% or higher. Also provided is a process for purifying 2-fluoro-3-oxoalkylcarboxylic acid ester characterized in that 2-fluoro-3-oxoalkylcarboxylic acid ester is produced at high yield and with less impurities by washing fluorinated 3-oxoalkylcarboxylic acid ester with 3 or more times as much water as the amount of reaction mixture. According to the processes of the present invention, not only is the generation of unwanted by-products minimized, but fluorinated 3-oxoalkylcarboxylic acid ester can be purified in an efficient manner. Thus, the present invention permits efficient production of considerably pure 2-fluoro-3-oxoalkylcarboxylic acid ester, a useful intermediate material in the production of various medical and agricultural agents.
