18092-54-1 Usage
Description
4-Methoxy-2-nitrobenzenesulfonyl Chloride is a chemical compound utilized in synthetic organic chemistry. It is characterized by a benzene ring with a nitro group (NO2), a methoxy group (OCH3), and a sulfonyl chloride group (SO2Cl). 4-METHOXY-2-NITROBENZENESULFONYL CHLORIDE is known for its high reactivity due to the presence of the sulfonyl chloride group, which makes it a potent electrophile. Its unique characteristics and reactivity make it a valuable intermediate in various chemical reactions and transformations. Due to its corrosive nature, extra precautions should be taken during its handling.
Uses
Used in Synthetic Organic Chemistry:
4-Methoxy-2-nitrobenzenesulfonyl Chloride is used as a chemical intermediate for various synthetic organic chemistry applications. Its reactivity, stemming from the sulfonyl chloride group, allows it to participate in a range of chemical reactions, making it a versatile component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Methoxy-2-nitrobenzenesulfonyl Chloride is used as a key building block in the synthesis of certain drugs. Its high reactivity enables the formation of new chemical entities that can be further developed into potential therapeutic agents.
Used in Chemical Research:
4-Methoxy-2-nitrobenzenesulfonyl Chloride is employed as a research tool in chemical laboratories. Its unique reactivity and structure make it an interesting subject for studying reaction mechanisms, exploring new synthetic pathways, and understanding the properties of sulfonyl chloride-containing compounds.
Used in Material Science:
In material science, 4-Methoxy-2-nitrobenzenesulfonyl Chloride is used as a precursor in the development of new materials with specific properties. Its reactivity can be harnessed to create novel polymers, coatings, or other materials with tailored characteristics for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 18092-54-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,0,9 and 2 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 18092-54:
(7*1)+(6*8)+(5*0)+(4*9)+(3*2)+(2*5)+(1*4)=111
111 % 10 = 1
So 18092-54-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H12N2Si/c1-9(2,3)8-6-4-5-7-8/h4-6H,1-3H3
18092-54-1Relevant articles and documents
Novel benzopyridothiadiazepines as potential active antitumor agents
Lebegue, Nicolas,Gallet, Sebastien,Flouquet, Nathalie,Carato, Pascal,Pfeiffer, Bruno,Renard, Pierre,Léonce, Stéphane,Pierré, Alain,Chavatte, Philippe,Berthelot, Pascal
, p. 7363 - 7373 (2007/10/03)
The synthesis of novel thiadiazepine derivatives, that could be considered as constraint analogues of E-7010, are reported. These molecules were evaluated for their antiproliferative activity toward the murine L1210 leukemia cell line. Flow cytometric studies performed on L1210 cells with the most cytotoxic compounds showed an accumulation of the cells in the G2/M phases of the cell cycle with a significant percentage of tetraploid cells (8N DNA content). Submicromolar cytotoxicities were observed with compounds 2b, 4b, 4e, 4g, and 4i. Two of them, compounds 2b and 4b, were found to be potent inhibitors of tubulin polymerization with IC50 of respectively 3.8 and 2.4 μM compared to 2.4 μM for desoxypodophyllotoxin. A 4-methoxyphenylethyl substitution on the pyridinyl nitrogen of the benzopyridothiadiazepine was found to be essential for the antiproliferative activity. The in vitro activities of compounds 2b and 4b make benzopyridothiadiazepine dioxides a promising new class of tubulin binders which warrant further in vivo evaluation.
