18495-26-6Relevant articles and documents
Palladium(II)-catalyzed carbocyclization: Vinylpalladium in 1,4-oxidation of conjugated dienes
Nilsson, Ylva I. M.,Gatti, Roberto G. P.,Andersson, Pher G.,Baeckvall, Jan-E.
, p. 7511 - 7523 (1996)
Palladium-catalyzed 1,4-oxidation of conjugated dienes involving carbon-carbon bond formation has been realized. The reaction is performed with both acyclic and cyclic dienes with a carbon chain containing a terminal or internal triple bond. A vinylpalladium species formed by chloropalladation of the alkyne inserts one of the double bonds of the diene in a Heck-type reaction. The addition of palladium and chloride over the triple bond is non-stereoselective while the overall 1,4-addition by carbon and chloride over the diene is highly stereoselective and occurs anti. The stereoselectivity of the chloropalladation is dependent on the chloride concentration and varies with the substrate.
Iodocyclization of hydroxylamine derivatives based on the control of oxidative aromatization leading to 2,5-dihydroisoxazoles and isoxazoles
Okitsu, Takashi,Sato, Kana,Potewar, Taterao M.,Wada, Akimori
experimental part, p. 3438 - 3449 (2011/06/26)
An efficient method for the synthesis of 2,5-dihydroisoxazoles and isoxazoles using iodocyclization of N-alkoxycarbonyl O-propargylic hydroxylamines has been developed. 2,5-Dihydro-4-iodoisoxazole underwent the cross-coupling reactions without aromatization to afford polyfunctionalized 2,5-dihydroisoxazoles. This process was applied to the preparation of valdecoxib and its 2,5-dihydro-derivative.
Efficient control for the cationic platinum(II)-catalyzed concise synthesis of two types of fused carbocycles with angular oxygen functionality
Kusama, Hiroyuki,Watanabe, Eiichi,Ishida, Kento,Iwasawa, Nobuharu
supporting information; experimental part, p. 2273 - 2277 (2012/06/30)
Double trouble: An efficient method for the preparation of two types of synthetically useful bicyclo[5.4.0]undecanes with an angular oxygen functionality was realized starting from easily available substrates; this method was based on the [3+2] cycloaddit