18542-42-2Relevant articles and documents
Synthesis in solution of peptoids using Fmoc-protected N-substituted glycines
Kruijtzer, John A. W.,Liskamp, Rob M. J.
, p. 6969 - 6972 (1995)
A convenient synthesis of Fmoc-protected N-substituted glycine derivatives starting from ethyl bromoacetate is described. As an illustration of the use of these building blocks for the preparation of peptoids, the synthesis of the C-terminal penta retropeptoid of Substance P (SP) is shown.
Synthesis and optical properties of sulfur-containing monomers and cyclomatrix polyphosphazenes
Fushimi, Toshiki,Allcock, Harry R.
, p. 5349 - 5355 (2010)
Novel cyclotriphosphazenes with sulfur-containing spirocyclic side groups were synthesized and polymerized to cyclomatrix materials for potential optical applications. The cyclotriphosphazenes were designed to give a high content of the phosphazene unit and sulfur atoms, as well as the capability for polymerization by ring- opening of the side groups. The chemical structures of the monomers were confirmed by NMR spectrometry, mass spectrometry, and single-crystal X-ray diffraction. Transparent solids were obtained by thermal bulk polymerization, and these were analyzed by the use of DSC, infrared spectroscopy, and mass spectrometry. One of the resultant cyclomatrix polyphosphazenes had a refractive index at 589 nm of 1.6465 and an Abbe number of 39. The contribution of the phosphazene unit to the refractive index is discussed.
Application of sulforaphane and derivatives thereof as bacterial effector protein transcription inhibitor
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Paragraph 0073; 0075-0077, (2021/03/31)
The invention discloses application of sulforaphane and derivatives thereof as a bacterial effector protein transcription inhibitor. The invention provides an application of sulforaphane and derivatives thereof in any one of application of the following 1) and 7): 1) prevention and treatment of pathogenic bacteria; 2) improvement of the resistance of plants to pathogenic bacteria; 3) inhibiting ofpathogenicity of pathogenic bacteria; 4) inhibiting of the function of a pathogenic bacterium III type secretion system; 5) inhibiting of the expression of effector protein related genes of a pathogenic bacterium type III secretion system; 6) inhibiting of the expression of a pathogenic bacteria transcription factor hrpL; and 7) using as a pathogenic bacteria effector protein transcription inhibitor. Experiments prove that the sulforaphane and the derivatives thereof can inhibit the function of a pathogenic bacteria type III secretion system by specifically inhibiting transcription of the pathogenic bacteria type III secretion system, can resist invasion of pathogenic bacteria without destroying interaction between plants and beneficial microorganisms, and have a wide application prospectin prevention and treatment of plant pathogenic bacteria.
SYNTHESIS OF FLUORO HEMIACETALS VIA TRANSITION METAL-CATALYZED FLUORO ESTER AND CARBOXAMIDE HYDROGENATION
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Paragraph 0194, (2020/11/24)
This application is directed to use of transition metal-ligand complexes to hydrogenate fluorinated esters and carboxamides into fluorinated hemiacetals. Methods for synthesis of certain ligands are also provided.
Preparation method of lapatinib intermediate 2-(methanesulfonyl)ethylamine hydrochloride
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Paragraph 0011; 0038-0040, (2017/10/13)
The invention discloses a preparation method of lapatinib intermediate 2-(methanesulfonyl)ethylamine hydrochloride. The preparation method comprises the steps of adopting 2-chloroethylamine hydrochloride (Compound 2) as a starting material, and under an alkaline condition, carrying out dimolecular substitution reaction on the starting material and sodium methyl mercaptide to prepare 2-methylmercapto ethylamine (Compound 3); then adopting water as a solvent, adding hydrochloric acid for salifying, and directly using hydrogen peroxide for oxidizing to obtain the 2-(methanesulfonyl)ethylamine hydrochloride (Compound 1). According to the preparation method provided by the invention, a synthetic route is short, the raw materials are simple and easy to get, the water is adopted as the solvent, the reaction condition is moderate, the after-treatment is simple, and the obtained product is good in quality and high in yield. The method can cause less three wastes, and is environmentally friendly and suitable for industrial production. The formula is shown in the specification.
