185426-15-7Relevant articles and documents
Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors
Chan, Grace Ka Yan,Chen, Huifen,Chen, Yong,Dimitrova, Yoana N.,Hu, Dennis X.,Huang, Haochu,Lee, Joanna Y.,Lim, Junghyun,McNamara, Erin,Moffat, John G.,Murthy, Aditya,Pang, Jodie,Patel, Snahel,Prangley, Madeleine S.,Salphati, Laurent,Schutt, Leah K.,Siu, Michael,Sneeringer, Christopher J.,Staben, Steven T.,Wallweber, Heidi Ackerly,Wang, Shumei,Wang, Yunli,Wu, Kai C.,Zhao, Wensheng
supporting information, (2021/12/02)
VPS34 is a class III phosphoinositide 3-kinase involved in endosomal trafficking and autophagosome formation. Inhibitors of VPS34 were believed to have value as anticancer agents, but genetic and pharmacological data suggest that sustained inhibition of V
GLYCOSAMINOGLYCAN DERIVATIVE AND METHOD FOR PRODUCING SAME
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Paragraph 0472-0476, (2016/06/28)
The present invention provides a glycosaminoglycan derivative in which a group derived from glycosaminoglycan and a group derived from a physiologically active substance having at least one of a carboxy group and a hydroxy group are coupled by covalent bond with a spacer therebetween, in which the spacer is selected in accordance with the decomposition rate of the covalent bond to the group derived from the physiologically active substance.
PRODUCTION OF OXY-MICHAEL ADDUCTS
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Page 14-15, (2010/02/08)
The invention provides a method of producing an oxy-Michael adduct comprising allowing a Michael acceptor to react with an alkoxide of an alcohol of formula R0H having a chiral centre at the hydroxy carbon, in the presence of a multidentate ligand. The