Welcome to LookChem.com Sign In|Join Free

CAS

  • or

185510-15-0

Post Buying Request

185510-15-0 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

185510-15-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 185510-15-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,5,1 and 0 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 185510-15:
(8*1)+(7*8)+(6*5)+(5*5)+(4*1)+(3*0)+(2*1)+(1*5)=130
130 % 10 = 0
So 185510-15-0 is a valid CAS Registry Number.

185510-15-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 6,7,8,9-tetrahydro-5H-pyrido<3,4-c>azepine

1.2 Other means of identification

Product number -
Other names 6,7,8,9-Tetrahydro-5H-pyrido[3,4-c]azepine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:185510-15-0 SDS

185510-15-0Downstream Products

185510-15-0Relevant articles and documents

Synthesis and binding of 6,7,8,9-tetrahydro-5H-pyrido[3,4-d]azepine and related ring-opened analogs at central nicotinic receptors

Cheng, Yun-Xing,Dukat, Malgorzata,Dowd, Matthew,Fiedler, Wolfgang,Martin, Billy,Damaj, Mohamed Imad,Glennon, Richard A.

, p. 177 - 190 (2007/10/03)

6,7,8,9-Tetrahydro-5H-pyrido[3,4-d]azepine (5a) and its N7-methyl derivative 5b were synthesized and evaluated as potential nicotinic acetylcholinergic receptor (nAChR) ligands. On the basis that 6,7,8,9- tetrahydro-5H-pyrido[3,4-c]azepine (4a), which binds at nAChRs with low affinity (K(i) = 1100 nM), possesses an internitrogen distance (4.6 A) that may be less than optimal, we designed compound 5a due to its similar shape but longer internitrogen distance (5.5 A). Compound 5a (K(i) = 46 nM) was found to bind with enhanced affinity. However, unlike what is seen with nornicotine/nicotine, N-methylation of 5a reduced affinity (5b; K(i) = 268 nM) rather than enhancing it. The results suggest that 5 may interact at nicotine receptors in a manner that is somewhat different from that of nicotine. Ring-opening of the pyrido[3,4-d]azepine ring led to a series of 3- (2-aminoethyl)pyridines 21 that retained the affinity of the cyclic compound. Subsequent modification, including further chain lengthening (e.g. aminopropylpyridines 22) and introduction of unsaturation, ultimately led to the development of a series of 3-(2-aminethoxy)pyridines 27. Simple N- substituted derivatives of 27 were found to bind with K(i) values of 20 to 35 nM. Because parallel structural changes in several series of related compounds did not result in parallel shifts in nAChR affinity, it is unlikely that all the investigated compounds bind in a similar fashion at these receptors. Nevertheless, some of these compounds represent novel classes of nAChR ligands.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 185510-15-0