18615-59-3 Usage
General Description
4-CHLORO-8-FLUORO-2-METHYLQUINOLINE, also known as 2-methyl-4-chloro-8-fluoroquinoline, is a chemical compound with a molecular formula C11H8ClFN. It is a quinoline derivative with a chloro and fluoro substitution at the 4 and 8 positions, respectively, and a methyl group at the 2 position. 4-CHLORO-8-FLUORO-2-METHYLQUINOLINE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has also been studied for its potential biological activities, including antimicrobial and antitumor properties. Additionally, 4-CHLORO-8-FLUORO-2-METHYLQUINOLINE is known to be an irritant to the skin, eyes, and respiratory system, and should be handled with proper safety precautions.
Check Digit Verification of cas no
The CAS Registry Mumber 18615-59-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,6,1 and 5 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 18615-59:
(7*1)+(6*8)+(5*6)+(4*1)+(3*5)+(2*5)+(1*9)=123
123 % 10 = 3
So 18615-59-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H7ClFN/c1-6-5-8(11)7-3-2-4-9(12)10(7)13-6/h2-5H,1H3
18615-59-3Relevant articles and documents
N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors
Luo, Wei,Liu, Yang,Wang, Jian,Guo, Chun,Lu, Wei-Qiang,Cui, Kun-Qiang
, p. 3073 - 3079,7 (2020/08/20)
A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.
