18709-01-8Relevant articles and documents
Application of copper(II)-mediated radical cross-dehydrogenative coupling to prepare spirocyclic oxindoles and to a formal total synthesis of Satavaptan
Hurst, Timothy E.,Gorman, Ryan,Drouhin, Pauline,Taylor, Richard J.K.
, p. 6485 - 6496 (2018)
Application of radical cross-dehydrogenative coupling (CDC) procedures to prepare a range of novel spirocyclic oxindoles and to a formal total synthesis of the vasopressin V2 receptor antagonist Satavaptan is reported. The key step involves a c
Mechanism of the Carboxylation of Cyclohexanone with Carbon Dioxide Catalyzed by 1,8-Diazabicycloundec-7-ene
Mori, Hisakazu
, p. 435 - 440 (1988)
The dependence of the rate of carboxylation upon the concentration of the reactant was investigated in dimethyl sulfoxide.The reaction rate depended upon the concentration of cyclohexanone and 1,8-diazabicycloundec-7-ene(DBU) in the first order, re
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Bottaccio,Chiusoli
, p. 618 (1966)
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Enantioselective Synthesis of Medium-Sized-Ring Lactones via Iridium-Catalyzed Z-Retentive Asymmetric Allylic Substitution Reaction
Ding, Lu,Song, Hao,Zheng, Chao,You, Shu-Li
supporting information, p. 4770 - 4775 (2022/03/27)
Medium-sized rings are important structural units, but their synthesis, especially in a highly enantioselective manner, has been a great challenge. Herein we report an enantioselective synthesis of medium-sized-ring lactones by an iridium-catalyzed Z-retentive asymmetric allylic substitution reaction. The reaction features mild conditions and a broad substrate scope. Various eight- to 11-membered-ring lactones can be afforded in moderate to excellent yields (up to 88%) and excellent enantioselectivity (up to 99% ee). The utilization of both Z-allyl precursors and an Ir catalyst is critical for the medium-sized-ring formation.
Amide derivative, preparation method of amide derivative, and application of amide derivative to pharmacy
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Paragraph 0250-0253, (2017/08/30)
The invention provides an amide derivative, a preparation method of the amide derivative, and application of the amide derivative to pharmacy. The amide derivative compound is selected from one of the following structures. The compound can be used for preparing medicines in the fields of local anaesthesia or analgesia. (The formulas are as shown in the description).
