18712-20-4Relevant articles and documents
Synthetic method for preparing saccharin (by machine translation)
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Paragraph 0079-0080, (2020/07/02)
1,2 - Benzisothiazol -3 - ketone compounds are subjected to an oxidation reaction with an oxidizing agent, and an oxidizing agent oxidizes thioether of 1,2 - benzisothiazol -3 -one compound to thioamide to obtain the O-benzoyl sulfamide compound. Compared with the traditional production technology of saccharin, the saccharin synthesis method has the advantages of simple process, low cost, high separation efficiency, low pollution and the like, and accords with the green chemistry. (by machine translation)
Regioselective alkylation of saccharin with alcohols under Mitsunobu conditions
Wang, Xiaolong,Ma, Yanying,Ju, Tingting
, p. 417 - 419 (2013/09/12)
The regioselective Mitsunobu alkylation of saccharin with various alcohols has been examined. The N/O-alkylation is dependent on the steric hindrance of the alcohols, that is, less sterically hindered alcohol preferentially afford N-alkylated saccharin an
New synthetic method to 1,2-benzisothiazoline-3-one-1,1- dioxides and 1,2-benzisothiazoline-3-one-1-oxides from N-alkyl(o- methyl)arenesulfonamides
Katohgi, Masashi,Togo, Hideo,Yamaguchi, Kentaro,Yokoyama, Masataka
, p. 14885 - 14900 (2007/10/03)
Various N-alkylsaccharins were easily prepared in moderate to good yields by the reaction of N-alkyl(o- methyl)arenesulfonamides with (diacetoxyiodo)benzene in the presence of iodine under irradiation with a tungsten lamp (W-hv). On the other hand, irradiation of N- alky](omethyl)arenesulfonamide derivatives bearing various substituents on the aromatic ring with a high-pressure mercury lamp (Hg-hv), in the presence of (diacetoxyiodo)benzene and iodine gave the corresponding N-alkyl-1,2-benzisothiazoline-3- one-1-oxide derivatives in moderate yields, together with N- alkyl-1,2-benzisothiazoline-3-one-1,1-dioxide (saccharin) derivatives.
