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187537-22-0

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187537-22-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 187537-22-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,7,5,3 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 187537-22:
(8*1)+(7*8)+(6*7)+(5*5)+(4*3)+(3*7)+(2*2)+(1*2)=170
170 % 10 = 0
So 187537-22-0 is a valid CAS Registry Number.

187537-22-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[(2R)-2-hydroxy-3-naphthalen-1-yloxypropyl]acetamide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:187537-22-0 SDS

187537-22-0Downstream Products

187537-22-0Relevant articles and documents

Enantioselective N-acetylation of N-desisopropylpropranolol by rat liver acetyltransferase

Wu, Xiuzhong,Ono, Yoko,Noda, Atsuko,Noda, Hiroshi

, p. 1361 - 1363 (2007/10/03)

The enantioselective N-acetylation of N-desisopropylpropranolol (NDP), one of the main metabolites of propranolol (PL), by rat liver acetyltransferase (AT), was investigated. R(+)-NDP or S(-)-NDP was used as a substrate at concentrations ranging from 10 to 200 μM. The cytosol fraction of a rat liver containing 3.93 mg protein/ml served as the source of AT. For 1-amino-3-(1-naphthyloxy)-2-propanol (AcNDP) formation from R(+)-NDP or s(- )-NDP in the presence of infinite AcCoA (250 μM), the K(m) value was calculated to be 67.5 or 62.4 μM, and the V(max) value was 0.462 or 0.205 nmol/min/mg protein. Based on these findings, the enantioselective N- acetylation of NDP was proved, i.e., AcNDP formation from R(+)-NDP was found to take place more easily than that from S(-)-NDP. Furthermore, AcNDP formation from NDP was competitively inhibited by the exogenous arylamine, p- aminobenzoic acid (PABA), which is well-known to be a typical substrate of AT. The presence of enantioselective inhibition for AcNDP formation was thus confirmed based on the K(i) values, 440 μM in the case of R(+)-NDP and 250 μM in the case of S(-)-NDP, respectively, i.e. two-fold enantioselective inhibition was demonstrated based on the Ki values in S(-)-enantiomer in comparison with R(+)-enantiomer.

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