188744-83-4

• 

• Basic information

  1. Product Name: 4H-1,3-Dioxolo4,5-cpyrrole, 4-(4-bromophenyl)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, (3aS,4S,6R,6aR)-
  2. Synonyms: 4H-1,3-Dioxolo4,5-cpyrrole, 4-(4-bromophenyl)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, (3aS,4S,6R,6aR)-
  3. CAS NO:188744-83-4
  4. Molecular Formula: C₂₀H₃₂BrNO₃Si
  5. Molecular Weight: 442.46
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 188744-83-4.mol
  9. Article Data: 2

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: /
  5. Density: N/A
  6. Refractive Index: N/A
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. CAS DataBase Reference: 4H-1,3-Dioxolo4,5-cpyrrole, 4-(4-bromophenyl)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, (3aS,4S,6R,6aR)-(CAS DataBase Reference)
  10. NIST Chemistry Reference: 4H-1,3-Dioxolo4,5-cpyrrole, 4-(4-bromophenyl)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, (3aS,4S,6R,6aR)-(188744-83-4)
  11. EPA Substance Registry System: 4H-1,3-Dioxolo4,5-cpyrrole, 4-(4-bromophenyl)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, (3aS,4S,6R,6aR)-(188744-83-4)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 188744-83-4(Hazardous Substances Data)

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• SDS
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• Downstream Products
• Article

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• (3AS,4S,6R,6AR)-4-(4-BROMOPHENYL)-6-[[[(TERT-BUTYL)DIMETHYLSILYL]OXY]METHYL]TETRAHYDRO-2,2-DIMETHYL-4H-1,3-DIOXOLO[4,5-C]PYRROLECAS

  Cas No: 188744-83-4

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188744-83-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 188744-83-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,7,4 and 4 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 188744-83:
(8*1)+(7*8)+(6*8)+(5*7)+(4*4)+(3*4)+(2*8)+(1*3)=194
194 % 10 = 4
So 188744-83-4 is a valid CAS Registry Number.

188744-83-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name	(1S)-1-(4-bromophenyl)-5-O-tert-butyldimethylsilyl-1,4-dideoxy-1,4-imino-2,3-O-isopropylidene-D-ribitol

1.2 Other means of identification

Product number	-
Other names	(3aS,4S,6R,6aR)-4-(4-Bromo-phenyl)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:188744-83-4 SDS

188744-83-4Upstream product

• 22480-64-4 4-bromophenyllithium 
• 153172-33-9 (3aR,4R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyl-4,6a-dihydro-3aH-[1,3]dioxolo[4,5-c]pyrrole 
• 106-37-6 1.4-dibromobenzene 
• 153172-32-8 (3aR,4R,6aS)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-chloro-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole 
• 153172-31-7 (3aR,4R,6aS)-4-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyrrole 

188744-83-4Downstream Products

• 188744-88-9 4-[(3aS,4S,6R,6aR)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-4-yl]-benzoic acid 
• 253129-07-6 4-((2S,3S,4R,5R)-3,4-Dihydroxy-5-hydroxymethyl-pyrrolidin-2-yl)-benzonitrile 
• 258834-86-5 (1S)-5-O-tert-butyldimethylsilyl-1-(4-cyanophenyl)-1,4-dideoxy-1,4-imino-2,3-O-isopropylidene-D-ribitol 
• 188744-97-0 1-(S)-(4-bromophenyl)-1,4-dideoxy-1,4-imino-D-ribitol 

188744-83-4Relevant articles and documents

Transition state analogue inhibitors of protozoan nucleoside hydrolases

Furneaux, Richard H.,Schramm, Vern L.,Tyler, Peter C.

, p. 2599 - 2606 (2007/10/03)

Protozoan parasites are unable to synthesize purines de novo and must rely on purine salvage pathways for their requirements. Nucleoside hydrolases, which are not found in mammals, function as key enzymes in purine salvage in protozoa. Inhibition of these enzymes may disrupt purine supply and specific inhibitors are potential therapeutic agents for the control of protozoan infections. A series of 1,4-dideoxy-1,4-imino-D-ribitols bearing C- bonded aromatic substituents at C-1 have been synthesized, following carbanion additions to the imine 2, and tested as potential nucleoside hydrolase inhibitors. Nucleoside analogues 8, 11, 14, 17, 20, 24-26, 28 exhibit K(i) values in the range 0.2-22 μM against two representative isozymes of protozoan nucleoside hydrolases. (C) 1999 Elsevier Science Ltd.

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